1
Beppu Teruhiko, Horinouchi Sueharu, Nishiyama Makoto, Yu Fujio, Hashimoto Yoshihiro: Hybrid plasmid vectors containing genes encoding nitrile degrading enzymes and methods of producing amides and acids.. Nitto Chemical, Beppu Teruhiko, September 9, 1992: EP0502476-A2 (43 worldwide citation)

The present invention provides a recombinant plasmid comprising combining a hybrid plasmid vector with the isolated DNA sequences of one or more genes encoding nitrile degrading enzymes which are derived from bacteria belonging to the genus Rhodococcus, said hybrid plasmid vector comprising an isola ...


2
Beppu Teruhiko, Yamada Hideaki, Nagasawa Toru Dr, Horinouchi Sueharu, Nishiyama Makoto Dr: Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the dna fragment and a process for the production of amides using the transformant.. Nitto Chemical, Beppu Teruhiko, Hideaki Yamada, September 11, 1991: EP0445646-A2 (21 worldwide citation)

The present invention discloses the amino acid sequence and nucleotide sequence of the alpha - and beta -subunits of two types of nitrile hydratase derived from Rhodococcus rhodochrous J-l. The DNA fragment encoding nitrile hydratase is inserted into an expression vector and the recombinant vector i ...


3
Nishino Norikazu, Yoshida Minoru, Horinouchi Sueharu, Komatsu Yasuhiko, Mimoto Tsutomu: Novel cyclic tetrapeptide derivatives and medicinal use thereof. Japan Energy, June 21, 2000: EP1010705-A1 (16 worldwide citation)

Cyclic tetrapeptide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, cyclic tetrapeptide compounds analogous thereto, and histone deacetylase inhibitors, MHC class-1 molecule expression promoters and medicinal compositions containing these cyclic tetrapept ...


4
Nishino Norikazu, Yoshida Minoru, Horinouchi Sueharu, Komatsu Yasuhiko: Novel cyclic tetrapeptide derivatives and use thereof as drugs. Japan Energy, January 23, 2002: EP1174438-A1 (9 worldwide citation)

The present invention provides a cyclic tetrapeptide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R21 and R22 independently denotes hydrogen, a linear C1-C6-alkyl group to which a non-aromatic cycloalkyl group or an option ...


5
Nakajima Hidenori, Tanaka Akito, Yoshida Minoru, Horinouchi Sueharu: Reduced fk228 and use thereof. Fujisawa Pharmaceutical Co, April 16, 2003: EP1302476-A1 (7 worldwide citation)

The present invention relates to reduced FK228 of the formula (I) wherein R and R are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter ...


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Kawauchi Hiroyuki Taisho Pharm, Sasaki Joji Taisho Pharmaceuti, Adachi Takashi Taisho Pharma C, Hanada Kazunori Taisho Pharma, Beppu Teruhiko, Horinouchi Sueharu: Vitamin d hydroxylase gene.. Taisho Pharma, May 17, 1995: EP0653490-A1 (5 worldwide citation)

A gene having the activity of a hydroxylase that can convert the hydrogen atom at the 25-position of a vitamin D into a hydroxyl group is obtained from the strain of an actinomyces of the genus Nocardia or Amycolata. A 25-hydroxylated vitamin D can be prepared efficiently in a high yield by transfor ...


8
Yoshida Minoru, Horinouchi Sueharu, Nishi Kazunori: Inhibitor protein of transcription factors and its dna. Takeda Chemical Industries, August 5, 1998: EP0856582-A2 (5 worldwide citation)

A protein which comprises the same or substantially the same amino acid sequence as that represented by SEQ ID NO: 1, its partial peptide and their salts are disclosed. DNA encoding the protein or its partial peptide is also disclosed. The protein, its partial peptide or a salt thereof is an inhibit ...


9
Beppu Teruhiko, Yamada Hideaki, Nagasawa Toru, Horinouchi Sueharu, Nishiyama Makoto: A gene encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant.. Nitto Chemical, Beppu Teruhiko, Hideaki Yamada, September 4, 1991: EP0444639-A2 (4 worldwide citation)

The present invention relates to a gene derived from Pseudomonas chlororaphis B23 strain which encodes a polypeptide having nitrile hydratase activity being capable of hydrating nitriles to amides. The invention also relates to a recombinant DNA containing the gene, and a transformant transformed wi ...


10
Beppu Teruhiko, Tonouchi Naoto, Horinouchi Sueharu, Tsuchida Takayasu: Acetobacter, plasmid originating therein, and shuttle vector constructed from said plasmid.. Bio Polymer Res, March 29, 1995: EP0645455-A1 (3 worldwide citation)

An Acetobacter sp. BPR 2001 strain, an endogenous plasmid pAH4 originating therein, and a shuttle vector constructed from the plasmid and a plasmid originating in Escherichia coli. This vector can be utilized in the genetic recombination of cellulose-producing acetobacters.



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