1
Lee Funk
Jingrong Jean Cui, Dilip Bhumralkar, Iriny Botrous, Ji Yu Chu, Lee A Funk, Cathleen Elizabeth Hanau, G Davis Harris, Lei Jia, Joanne Johnson, Stephen A Kolodziej, Pei Pei Kung, Xiaoyuan, Jason, Jerry Jialun Meng, Mitchell David Nambu, Christopher G Nelson, Mason Alan Pairish, Hong Shen, Michelle Tran Dube, Allison Walter, Fang Jie Zhang, Jennifer Zhang: Aminoheteroaryl compounds as protein kinase inhibitors. Sugen, Foley & Lardner, June 12, 2007: US07230098 (22 worldwide citation)

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET


2

3
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Jeffrey H Tidwell, Stephen D Prodnuk, Vincent P Liptak, December 28, 2010: US07858643 (6 worldwide citation)

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


4
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Agouron Pharmaceuticals, March 2, 2006: US20060046991-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


5
Lee Funk
Jingrong Jean Cui, Dilip Bhumralkar, Iriny Botrous, Ji Yu Chu, Lee A Funk, Cathleen Elizabeth Hanau, G Davis Harris, Lei Jia, Joanne Johnson, Stephen A Kolodziej, Pei Pei Kung, Xiaoyuan, Jason, Jerry Jialun Meng, Mitchell David Nambu, Christopher G Nelson, Mason Alan Pairish, Hong Shen, Michelle Tran Dube, Allison Walter, Fang Jie Zhang, Jennifer Zhang: Aminoheteroaryl compounds as protein kinase inhibitors. Sugen, Foley And Lardner, March 29, 2007: US20070072874-A1

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.


6
Lee Funk
Jingrong Jean Cui, Dilip Bhumralkar, Iriny Botrous, Ji Yu Chu, Lee A Funk, Cathleen Elizabeth Hanau, G Davis Harris, Lei Jia, Joanne Johnson, Stephen A Kolodziej, Pei Pei Kung, Xiaoyuan Li, Jason Lin, Jerry Jialun Meng, Mitchell David Nambu, Christopher G Nelson, Mason Alan Pairish, Hong Shen, Michelle Tran Dube, Allison Walter, Fang Jie Zhang, Jennifer Zhang: Aminoheteroaryl compounds as protein kinase inhibitors. Sugen, Foley And Lardner, January 13, 2005: US20050009840-A1

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.


7
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, October 18, 2012: US20120263706-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


8
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Pfizer, December 23, 2010: US20100324061-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


9
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Agouron Pharmaceuticals, June 15, 2006: US20060128724-A1

Compounds of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


10
Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Agouron Pharmaceuticals, August 10, 2006: US20060178374-A1

Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.