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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (52 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (51 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


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Holy Antonin Rndr, Rosenberg Ivan, de Clercq Erik Prof Dr: N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity.. Ceskoslovenska Akademie Ved, Rega Foundation, January 20, 1988: EP0253412-A2 (46 worldwide citation)

This invention relates to new nucleotide analogues exhibiting antiviral activity which represent N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases and to methods for their preparation and to their use in pharmaceutical compositions. T ...


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Holy Antonin, Rosenberg Ivan, Slama Karel: Isomeric o-phosphonylmethyl derivatives of enantiomeric and racemic vicinal diols and method of preparing them. Ceskoslovenska Akademie Ved, August 22, 1984: GB2134907-A (24 worldwide citation)

Dérivés O-phosphonylméthyliques isomères de diols vicinaux énantiomères et racémiques et procédé de leur préparation ; les composés de l'invention répondent à la formule générale I : (CF DESSIN DANS BOPI) dans laquelle R**1 désigne un atome d'hydrogène, un radical alkyle ayant 1 à 3 atomes de carbon ...


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Holy Antonin, Jindrich Jindrich, Balzarini Jan, de Clercq Erik: Antiretroviral bases.. Ceskoslovenska Akademie Ved, Univ Rega Katholieke, October 30, 1991: EP0454427-A1 (8 worldwide citation)

The present invention relates to N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, useful against retroviruses.


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Holy Antonin, Dvorakova Hana, Declercq Erik Desire Alice, Balzarini Jan Marie Rene: Antiretroviral enantiomeric nucleotide analogs.. Acad Of Science Czech Republic, Rega Stichting, May 24, 1995: EP0654037-A1 (3 worldwide citation)

Resolved enantiomers of formulae (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.


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Holy Antonin, de Clercq Erik Desire Alice: Novel compounds and methods for therapy. Ustav Organicke Chemie A Bioch, Rega Stichting, February 4, 1998: EP0821690-A1 (2 worldwide citation)

Novel PMP, PME and HPMP and related compounds containing N and/or 2-substituted 2,6-diaminopurine, 2-aminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeuti ...



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