1
Bosslet Klaus Dr, Czech Joerg Dr, Hoffmann Dieter Dr: Bifunctional glycoproteins having a modified carbohydrate complement, and their use in tumorselective therapy.. Behringwerke, November 9, 1994: EP0623352-A2 (29 worldwide citation)

Provided herein are carbohydrate complement-modified bifunctional glycoproteins, and their use in tumor-selective therapy. The bifunctional glycoproteins comprise a first component that specifically binds to a tumor-specific antigen and a second component having enzymatic activity by means of which ...


2
Krone Volker Dr, Magerstaedt Michael Dr, Walch Axel Dr, Groener Albrecht Dr, Hoffmann Dieter Dr: Pharmacological product containing polyelectrolyte complexes in microparticulate form and at least one substance.. Hoechst, October 30, 1991: EP0454044-A2 (26 worldwide citation)

The invention relates to a pharmacological product containing a polyelectrolyte complex, in particular a polyacid with a median particle size of less than 15 mu m and an active substance, which includes active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflammatory ag ...


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Seemann Gerhard, Bosslet Klaus, Czech Joerg, Kolar Cenek, Hoffmann Dieter, Sedlacek Hans Harald: Fusion proteins with monoclonal antibody, linker and beta glucuronidase for prodrug activation. Behringwerke, September 2, 1992: EP0501215-A2 (20 worldwide citation)

The invention relates to fusion proteins for prodrug activation of the general formula huTuMAb-L- beta -gluc, where huTuMAb is a humanised or human tumour-specific monoclonal antibody or a fragment thereof, L is a linker and beta -gluc comprises human beta -glucuronidase. These fusion proteins are p ...


5
Gerken Manfred Dr, Krause Manfred, Czech Joerg Dr, Bosslet Klaus Dr, Seemann Gerhard Dr, Hoffmann Dieter Dr, Sedlacek Hans Harald Dr: Anthracycline-glycosyl prodrugs, process for their preparation and their use in combination with functionalised tumour-specific enzyme conjugates.. Behringwerke, August 14, 1991: EP0441218-A2 (13 worldwide citation)

The present invention relates to glycosyl-anthracycline prodrugs, to processes for their preparation and to their use in combination with functionalised tumour-specific enzyme conjugates for the treatment of cancers, and it specifically relates to 14-O-glycosyl-anthracyclines as prodrugs which can b ...


6
Bosslet Klaus Dr, Czech Joerg Dr, Hoffmann Dieter Dr, Tillequin Francois, Florent Jean Claude, Azoulay Michel, Monneret Claude, Jacquesy Jean Claude, Gesson Jean Pierre, Koch Michel: Pro-prodrugs, their production and use.. Behringwerke, Hoechst Lab, April 19, 1995: EP0648503-A1 (11 worldwide citation)

Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.


7
Heid Christian, Hoffmann Dieter, Polster Johannes: Use of perfluoralkylphosphorus compounds as foam-dampening agents. Cassella Farbwerke Mainkur, Connolly and Hutz, October 14, 1975: US3912654 (11 worldwide citation)

Process for dampening foaming of a liquid which employs a compound of the formulaR.sub.(3-x) PO(OH).sub.xOr an alkali metal or an alkali earth metal salt thereof as foam-dampening agent, R being C.sub.n F.sub.2.sub.+1, n being an integer from 4 to 24 and x being 1 or 2. The compounds used as foam-da ...


8
Widiger Hans, Hoffmann Dieter: Transport system for underground mining. November 27, 1973: US3774547 (8 worldwide citation)

A transport system for underground mining in which the cars, including the tractor and the trailer cars, have a plurality of supporting wheels in the form of flanged rollers provided with concavely curved surfaces which engage a track consisting of a pair of longitudinally extending convexly curved ...


9
Widiger Hans, Hoffmann Dieter: Mine car transportation system. Fraser Malcolm W, December 17, 1974: US3854421 (6 worldwide citation)

A transport system for underground mining in which the cars, including the tractor and the trailer cars, have a plurality of supporting wheels in the form of flanged rollers provided with concavely curved surfaces which engage a track consisting of a pair of longitudinally extending convexly curved ...


10
Hoffmann Dieter: Precision bearing.. Kern & Co, February 22, 1989: EP0304397-A1 (6 worldwide citation)

In a ball or roller bearing, permanent deformations of the rollers and tracks resulting from shocks are avoided by the bearing parts (1, 2, 11, 12) which move against one another having shoulders (7, 17) placed opposite one another at such a small distance (s, s') that they strike against one anothe ...



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