1
Hisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto: CETP activity inhibitors. Japan Tobacco, Fish & Richardson P C, July 30, 2002: US06426365 (36 worldwide citation)

The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I):


2
Motohide Satoh, Hiroshi Kawakami, Yoshiharu Itoh, Hisashi Shinkai, Takahisa Motomura, Hisateru Aramaki, Yuji Matsuzaki, Wataru Watanabe, Shuichi Wamaki: 4-oxoquinoline compound and use thereof as pharmaceutical agent. Japan Tobacco, Finnegan Henderson Farabow Garrett & Dunner, February 13, 2007: US07176220 (29 worldwide citation)

An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action a ...


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Shigeshi Toyoshima, Yoshiko Seto, Hisashi Shinkai, Koji Toi, Izumi Kumashiro: Hypoglycemic agent. Ajinomoto Co, Oblon Fisher Spivak McClelland & Maier, March 28, 1989: US04816484 (23 worldwide citation)

A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --CH(CH.sub.3)--OCO--R.sup. ...


5
Lawrence R McGee, Jonathan B Houze, Steven M Rubenstein, Atsushi Hagiwara, Noboru Furukawa, Hisashi Shinkai: Quinolinyl and benzothiazolyl modulators. Tularik, Japan Tobacco, Townsend and Townsend and Crew, June 24, 2003: US06583157 (22 worldwide citation)

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PAPAR&ggr;. In particular, the compounds of the invention modulate the function of PAPAR&ggr;. The subject methods are particularly useful in the treatment and/or pr ...


6
Hisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto: CETP activity inhibitor. Japan Tobacco, Leydig Voit & Mayer, June 22, 2004: US06753346 (16 worldwide citation)

The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I):


7
Kimiya Maeda, Hironobu Nagamori, Hiroshi Nakamura, Hisashi Shinkai, Yasunori Suzuki, Daisuke Takahashi, Toshio Taniguchi: Dibenzylamine compound and medicinal use thereof. Japan Tobacco, Leydig Voit & Mayer, February 19, 2008: US07332514 (7 worldwide citation)

A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom, a halogen atom and the like, or R3 and R4 may form, together with carbon atoms bonded thereto, a homocyc ...


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Hisashi Shinkai: Isoxazolidinedione compounds and use thereof. Japan Tobacco, Wenderoth Lind & Ponack, March 17, 1998: US05728720 (7 worldwide citation)

Novel isoxazolidinedione derivatives of the formula (I) ##STR1## wherein R is an optionally substituted aromatic hydrocarbon, an optionally substituted alicyclic hydrocarbon, an optionally substituted heterocyclic group, an optionally substituted condensed heterocyclic group or a group of the formul ...


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Lawrence R McGee, Steven M Rubenstein, Atsushi Hagiwara, Noboru Furukawa, Hisashi Shinkai: Quinolinyl and benzothiazolyl modulators. Amgen, Japan Tobacco, Jones Day, October 13, 2009: US07601841 (6 worldwide citation)

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention o ...


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Kouzou Toyota, Hisashi Shinkai, Hirozumi Eto, Akira Kamimura, Chikahiko Eguchi, Koji Ohsumi, Takashi Tsuruo: 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells. Ajinomoto Co, Japanese Foundation for Cancer Research, Sughrue Mion Zinn Macpeak & Seas, June 1, 1993: US05216172 (5 worldwide citation)

Agents against drug-resistant tumor cells comprising a 1,4-dihydropyridine derivative represented by the following formula (I): ##STR1## wherein R.sup.1 is an aryl group which may be substituted;