1
Seiji Yoshikawa, Eita Emori, Fumiyoshi Matsuura, Richard Clark, Hironori Ikuta, Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki, Mika Aoki: Xanthine derivative and DPPIV inhibitor. Eisai, Townsend and Townsend and Crew, July 11, 2006: US07074798 (76 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an ...


2
Yasutaka Takase, Nobuhisa Watanabe, Makoto Matsui, Hironori Ikuta, Teiji Kimura, Takao Saeki, Hideyuki Adachi, Tadakazu Tokumura, Hisatoshi Mochida, Yasunori Akita, Shigeru Souda: Benzimidazoles for ischemic heart conditions. Eisai, Nixon & Vanderhye, December 2, 1997: US05693652 (66 worldwide citation)

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ...


3
Fumihiro Ozaki, Keiji Ishibashi, Hironori Ikuta, Hiroki Ishihara, Shigeru Souda: Anthranilic acid derivatives. Eisai, Nixon & Vanderhye, February 10, 1998: US05716993 (49 worldwide citation)

The present invention provides an anthranilic acid derivative having a cGMP-PDE inhibitory activity.


4
Yasutaka Takase, Nobuhisa Watanabe, Makoto Matsui, Hironori Ikuta, Teiji Kimura, Takao Saeki, Hideyuki Adachi, Tadakazu Tokumura, Hisatoshi Mochida, Yasunori Akita, Shigeru Souda: Anti-ischemic 2,4-diaminoquinazolines. Eisai, Nixon & Vanderhye, November 19, 1996: US05576322 (48 worldwide citation)

The invention is directed to certain 2,4-diaminoquinazoline compounds, their pharmaceutically acceptable salts, the pharmaceutical compositions comprising those compounds and their therapeutic methods of use. The compounds possess anti-ischemic activity.


5
Yasutaka Takase, Nobuhisa Watanabe, Makoto Matsui, Hironori Ikuta, Teiji Kimura, Takao Saeki, Hideyuki Adachi, Tadakazu Tokumura, Hisatoshi Mochida, Yasunori Akita, Shigeru Souda: Quinazoline derivatives. Eisai, Nixon & Vanderhye, September 1, 1998: US05801180 (45 worldwide citation)

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ...


6
Ichirou Yoshida, Hironori Ikuta, Yoshio Fukuda, Yoshihito Eguchi, Makoto Kaino, Katsuya Tagami, Naoki Kobayashi, Kenji Hayashi, Hironobu Hiyoshi, Issei Ohtsuka, Makoto Nakagawa, Shinya Abe, Shigeru Souda: Phosphonic acid derivatives. Eisai, Birch Stewart Kolasch & Birch, February 17, 1998: US05719303 (21 worldwide citation)

A phosphonic acid derivative which is useful for medically treating hyperlipemia, represented by the following general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## Representative example of the compound according to the present invention is one represented by the following fo ...


7
Youji Yamagishi, Kozo Akasaka, Takeshi Suzuki, Mitsuaki Miyamoto, Kouji Nakamoto, Kazuo Okano, Shinya Abe, Hironori Ikuta, Kenji Hayashi, Hiroyuki Yoshimura, Tohru Fujimori, Koukichi Harada, Isao Yamatsu: Diphenylethylene derivatives, pharmaceutical compositions containing same and treatment methods. Eisai, Flynn Thiel Boutell & Tanis, July 23, 1991: US05034418 (16 worldwide citation)

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,


8
Yoshimasa Machida, Isao Saito, Isao Sugiyama, Shigeto Negi, Seiichiro Nomoto, Hironori Ikuta, Hiroshi Yamauchi, Kyosuke Kitoh: Cephalosporin compounds. Eisai, Wenderoth Lind & Ponack, August 28, 1984: US04468394 (15 worldwide citation)

A compound represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or hydroxy; R is ##STR2## wherein R.sub.3 and R.sub.4 are hydroxy or acyloxy, Y is oxygen, sulfur or >N-R.sub.5 wherein R.sub.5 is hydrogen or lower alkyl, and Z is sulfur or >N-R.sub.5 wherei ...


9
Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Seiji Yoshikawa, Daisuke Shinmyo, Nobuhisa Watanabe, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito: N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient. Eisai, Birch Stewart Kolasch and Birch, September 26, 2006: US07112593 (4 worldwide citation)

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n ...


10
Katsuya Tagami, Ichirou Yoshida, Naoki Kobayashi, Yoshio Fukuda, Yoshihito Eguchi, Makoto Nakagawa, Hironobu Hiyoshi, Hironori Ikuta, Makoto Kaino, Kenji Hayashi, Issei Ohtsuka, Shinya Abe, Shigeru Souda: Phosphorus-containing isoprenoid derivatives. Eisai, Flynn Thiel Boutell & Tanis, September 26, 1995: US05453524 (4 worldwide citation)

The present invention provides a phosphorus-containing isoprenoid derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is useful as a preventive and therapeutic agent for diseases for which a squalene synthetase inhibiting action is effica ...