1
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule and its production. Takeda Chemical, Wegner & Bretschneider, March 24, 1987: US04652441 (258 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


2
Shin ichiro Hirai, Hiroaki Okada, Takatsuka Yashiki: Takeda Chemical, Wenderoth Lind & Ponack, April 21, 1987: US04659696 (157 worldwide citation)

A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the mammalian body when administered by a non-oral or non-injection route.


3
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule of a water-soluble drug. Takeda Chemical, Wegner Cantor Mueller & Player, October 29, 1991: US05061492 (155 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


4
Hiroaki Okada, Shigeru Kamei, Toshio Yoshioka: Intravascular embolizing agent containing angiogenesis-inhibiting substance. Takeda Chemical, David G Conlin, David S Resnick, April 13, 1993: US05202352 (132 worldwide citation)

The present invention relates to an intravascular embolizing agent containing an angiogenesis-inhibiting substance and an intravascular embolizing substance. The agent strengthens the antitumor effect of an angiogenesis-inhibiting substance and serves to reduce the dose and undesirable side effects. ...


5
Hiroaki Okada, Yayoi Douken: Sustained-release preparation capable of releasing a physiologically active substance. Takeda Chemical, Wenderoth Lind & Ponack L, September 5, 2000: US06113943 (120 worldwide citation)

Disclosed is a sustained-release preparation comprising 1) a polymer of lactic acid having a weight-average molecular weight of about 25,000 to about 60,000 and 2) a physiologically active substance, and which releases the physiologically active substance over a period of at least about 5 months; th ...


6
Masaki Yamamoto, Hiroaki Okada, Yasuaki Ogawa, Tsutomu Miyagawa: Polymer, production and use thereof. Takeda Chemical, Wako Pure Chemical, Wegner & Bretschneider, March 1, 1988: US04728721 (103 worldwide citation)

The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.


7
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsules and their production. Takeda Chemical, Wegner & Bretschneider, December 8, 1987: US04711782 (95 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


8
Toshio Yoshioka, Hiroaki Okada, Yasuaki Ogawa: Sustained release microcapsule for water soluble drug. Takeda Chemical, Wegner Cantor Mueller & Player, December 21, 1993: US05271945 (88 worldwide citation)

Sustained release microcapsules including a water soluble drug and an organic basic substance as a drug retaining substance of this invention not only have a high rate of incorporation (trapping rate), but also show little initial release so that they can be administered safely and bring about persi ...


9
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsules. Takeda Chemical, Wegner & Bretschneider, April 17, 1990: US04917893 (88 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


10
Hiroaki Okada, Iwao Yamazaki, Takatsuka Yashiki: Takeda Chemical, Wenderoth Lind & Ponack, July 8, 1980: US04211769 (76 worldwide citation)

A preparation containing, as the main pharmaceutically active ingredient, a peptide having a luteinizing hormone-releasing hormone activity, is improved in its absorption by adding thereto a water-soluble aliphatic carboxylic acid of 2 to 6 carbon atoms.