1
Koester Hubert, Little Daniel P, Braun Andreas, Jurinke Christian, Van Den Boom Dirk, Xiang Guobing, Lough David M, Ruppert Andreas, Hillenkamp Franz: Dna diagnostics based on mass spectrometry. Sequenom, December 19, 2001: EP1164203-A2 (11 worldwide citation)

Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processed can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predispositio ...


2
Franzen G, Hillenkamp Franz, Kaufman Raimund, Remy Ernst: Method for evaporating, destroying, exciting and/or ionizing specimen material limited to micro-regions, and arrangement for carrying out this method. Remy Ernst, Bierman & Bierman, May 28, 1974: US3813544 (10 worldwide citation)

Method and apparatus for examining micro-regions of biologic specimens normally radiation absorptive in which a source of coherent electromagnetic radiation is optically focused on a selected region of the specimen. The power density is adjusted in the central diffraction disk to the point where the ...


3
Higgins Scott, Reuter Dirk, Lough David M, Hillenkamp Franz: Method and apparatus for maldi analysis. Sequenom, January 2, 2003: EP1271609-A2 (6 worldwide citation)

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


4
Hillenkamp Franz, Reuter Dirk, Higgins Scott, Lough David M: Method and apparatus for maldi analysis. Sequenom, October 7, 1998: EP0868740-A1 (5 worldwide citation)

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


5
Bank Walter, Feigl Peter, Heinen Hans Josef Dr, Hillenkamp Franz Prof Dr, Nitsche Rainer Dr, Schueler Bruno, Vogt Henning, Wechsung Reiner Dr: Laser microprobe for solid samples in which viewing optics, laser light optics and ion optics are arranged at the same side of a sample mounting.. Leybold Heraeus & Co Kg, September 21, 1983: EP0088917-A1 (3 worldwide citation)

1. A laser microprobe for solid-state samples, in which an observation lens means, a laser light lens means and an ion lens means are arranged on the same side of a sample holder and in which a time-of-flight mass spectrometer is used as the mass analyzer, characterized by the following features : a ...


6
Hillenkamp Franz, Reuter Dirk, Higgins Scott, Lough David M: Procede et dispositif pour analyse en desorption/ionisation laser assistee par matrice (maldi), Method and apparatus for maldi analysis. Sequenom, Sequenom, SMART & BIGGAR, March 26, 1998: CA2237946

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


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Hillenkamp Franz, Reuter Dirk, Higgins Scott, Lough David M: Method and apparatus for maldi analysis. Sequenom, SEIDMAN Stephanie, March 26, 1998: WO/1998/012734

Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpeni ...


9
Hillenkamp Franz, Köster Hubert: Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules. Sequenom, Hillenkamp Franz, Köster Hubert, sSEIDMAN Stephanie L, November 11, 1999: WO/1999/057318

Mixtures containing a biological macromolecule, such as a nucleic acid molecule or a polypeptide, and a liquid matrix, which absorbs infrared (IR) radiation, are provided. These mixtures are useful for analysis of the biological macromolecule by IR matrix assisted laser desorption/ionization (IR-MAL ...


10
Wenzel Ryan, Röhling Ulrich, Nazabal Alexis, Hillenkamp Franz: A detector device for high mass ion detection, a method for analyzing ions of high mass and a device for selection between ion detectors. Covalx, Wenzel Ryan, Röhling Ulrich, Nazabal Alexis, Hillenkamp Franz, FREI PATENTANWALTSBÜRO, July 16, 2009: WO/2009/086642

Described here is a detector for measuring heavy mass ions with high sensitivity and low saturation for time-of-flight mass spectrometry and a detector housing for selecting between multiple detectors. It relates to sensitive measuring methods of large masses in the range of about ten thousand to a ...