1
Theeuwes Felix, Higuchi Takeru: Osmatic dispensing device for releasing beneficial agent. Alza Corporation, Sabatine Paul L, Mandell Edward L, Benz William H, November 5, 1974: US3845770 (1481 worldwide citation)

A wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the composition is disclosed. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in the fluid and exhibits ...


2
Theeuwes Felix, Higuchi Takeru: Osmotic dispensing device with maximum and minimum sizes for the passageway. Alza Corporation, Sabatine Paul L, Mandell Edward L, Ciotti Thomas E, November 4, 1975: US3916899 (1286 worldwide citation)

A device is disclosed comprised of a wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the compostion. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in th ...


3
Higuchi Takeru, Leeper Harold M: Drug-delivery device with stretched, rate-controlling membrane. Alza Corporation, January 16, 1973: US3710795 (368 worldwide citation)

Drug-delivery device for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having drug dispersed therethrough. Surrounding the inner matrix is an intimately contacting outer polymeric membrane, insoluble in body fluids, which contracts ab ...


4
Higuchi Takeru: Drug-delivery device. Alza Corporation, December 7, 1971: US3625214 (231 worldwide citation)

A drug-delivery device for prolongedly delivering drugs to patients according to any predetermined time release profile, e.g., increasing, decreasing, constant, pulsing, sinusoidal, and like patterns of release, is fabricated by applying a drug coating of varying or uniform thickness to a relatively ...


5
Higuchi Takeru: Ocular insert. ALZA Corporation, December 28, 1971: US3630200 (138 worldwide citation)

Drug dispensing ocular insert for insertion into the cul-de-sac of the conjunctiva between the sclera of the eyeball and the lid to dispense drug to the eye over a prolonged period of time is rendered more compatible with the eye and surrounding tissues by fabricating the insert of an inner core con ...


6
Higuchi Takeru, Leeper Harold M: Osmotic dispenser. Alza Corporation, May 15, 1973: US3732865 (118 worldwide citation)

An osmotic active agent dispenser is comprised of (1) a first compartment of relatively impervious material containing an active agent and provided with an aperture for releasing said active agent to the exterior of the dispenser; (2) a second compartment of controlled permeability to water containi ...


7
Higuchi Takeru, Nishihata Toshiaki: An orally administered drug form comprising a polar bioactive agent and an adjuvant.. Interx Research, September 23, 1981: EP0036145-A1 (117 worldwide citation)

A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accept ...


8
Higuchi Takeru: Osmotic dispenser with collapsible supply container. Alza Corporation, September 25, 1973: US3760805 (98 worldwide citation)

An osmotic dispenser is comprised of (1) a water porous housing member confining (2) a first flexible bag of relatively impervious material containing an active agent and provided with active agent dispensing head, and (3) a second bag of controlled permeability to moisture containing a solution whi ...


9
Higuchi Takeru, Leeper Harold M: Improved osmotic dispenser employing magnesium sulphate and magnesium chloride. Alza Corporation, September 25, 1973: US3760804 (59 worldwide citation)

An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the motive force of which dispenser depends on the osmotic pressure developed by either (1) an aqueous solu ...


10
Higuchi Takeru: Osmotic dispenser. Alza Corporation, Bacon & Thomas, December 30, 1975: US3929132 (43 worldwide citation)

An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the active agent content of which dispenser is formulated in a form other than wholly in solution, namely, ...