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Higuchi Naoki, Saitoh Masayuki, Shibata Hiroshi: Proteinase inhibitor.. Suntory, October 24, 1990: EP0393457-A1 (170 worldwide citation)

A proteinase inhibitory compound represented by the following general formula (1): wherein R1 represents a straight-chain or branched acyl group having 2 to 10 carbon atoms, a branched-, cyclic- or polycyclic-alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted- or unsubstituted-benzylo ...


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Kiso Yoshinobu, Hayashi Yasuhiro, Higuchi Naoki, Saitoh Masayuki, Hashimoto Masaki: Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient.. Suntory, September 23, 1992: EP0504938-A2 (63 worldwide citation)

Use of a compound represented by the following general formula (I): wherein R represents a straight or branched acyl group having 2 to 10 carbon atoms, a branched cyclic or bridged cyclic alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted or unsubstituted benzyloxycarbonyl group, a 2, ...


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Higuchi Naoki, Saitoh Masayuki, Niwata Shinjiro, Kiso Yoshinobu, Hayashi Yasuhiro: Dipeptide derivative and prophylactic and therapeutic agent for bone diseases containing the same.. Suntory, May 26, 1993: EP0543310-A2 (30 worldwide citation)

A prophylactic or therapeutic agent for malignant hypercalcemia, bone Paget's disease and osteoporosis is disclosed, which contains as an active ingredient a dipeptide derivative represented by formula: RNH-CH(R)-CO-NH-CH(R)-R (I> wherein R represents an aliphatic acyl group, a halogen-substituted a ...


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Tanaka Takaharu, Saitoh Masayuki, Hashimoto Masaki, Higuchi Naoki: N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use.. Suntory, November 20, 1986: EP0201742-A2 (23 worldwide citation)

A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.


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Higuchi Naoki, Saitoh Masayuki, Niwata Shinjiro, Kiso Yoshinobu, Hayashi Yasuhiro: Dipeptide derivative and prophylactic or therapeutic agent for bone diseases containing same as active ingredient.. Suntory, January 19, 1994: EP0578978-A1 (10 worldwide citation)

A dipeptide derivative having the formula (I): RNH-CH(R)-CO-NH-CH(R)-COCH2F (I> wherein, R is an aliphatic acyl group having 2 to 8 carbon atoms or a benzyloxycarbonyl group; and R and R are independently a hydrogen atom or a straight or branched alkyl group having 1 to 4 carbon atoms and a prophyla ...


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Saitoh Masayuki, Tanaka Takaharu, Higuchi Naoki, Hashimoto Masaki, Fukami Harukazu: Pyrrolidineamide derivative having anti-prolyl endopeptidase activity, compositions comprising the same, processes for the preparation of the same, and the use of the same for the preparation of a medicament of therapeutic value.. Suntory, May 25, 1988: EP0268281-A2 (8 worldwide citation)

A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: wherein R is benzyloxycarbonyl or a group of the formula: (wherein ...


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NARISAKO MAKOTO, YAMAOKA TOSHIYUKI, KOBAYASHI DAISUKE, HIGUCHI NAOKI: [fr] Procédé pour séparer et récupérer du nickel et du lithium, [de] Verfahren zum Trennen und Wiedergewinnen von Nickel und Lithium, [en] Method for separating and recovering nickel and lithium. JX NIPPON MINING & METALS, April 6, 2011: EP2305841-A1 (3 worldwide citation)

[en] A method for extracting nickel and lithium includes solvent extraction step of using three or more extraction stages to subject a solution containing lithium and nickel to solvent extraction with 2-Ethylhexyl phosphonic acid mono-2-ethylhexyl ester at a pH of 8.0 to 8.5, whereby the nickel and ...