1
Masanobu Shinoda, Eita Emori, Fumiyoshi Matsuura, Toshihiko Kaneko, Norihito Ohi, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Sadakazu Miyashita, Taro Hibara, Takashi Seiki, Richard Clark, Hitoshi Harada: Carboxylic acid derivatives and drugs containing the same. Eisai, Birch Stewart Kolasch & Birch, April 26, 2005: US06884821 (23 worldwide citation)

Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a sin ...


2
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Benzene compound and salt thereof. Eisai, Birch Stewart Kolasch & Birch, July 17, 2007: US07244861 (11 worldwide citation)

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hyd ...


3
Richard Clark, Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Cyclic compound and PPAR agonist. Eisai, Birch Stewart Kolasch & Birch, May 13, 2008: US07371777 (5 worldwide citation)

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each re ...


4
Hitoshi Harada, Masanobu Shinoda, Richard Clark, Fumiyoshi Matsuura, Eita Emori, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Carboxylic acids. Eisai, Birch Stewart Kolasch & Birch, August 7, 2007: US07253178 (3 worldwide citation)

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formul ...


5
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara, Hitoshi Harada, Kaya Ohashi: Carboxylic acid derivative and salt thereof. Eisai R&D Management, Birch Stewart Kolasch & Birch, June 9, 2009: US07544835 (1 worldwide citation)

Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein R1 represents hydrogen, hydroxyl, halogen, carboxyl, or C1-6 alkyl, L represents single bond or C1-6-alkylene, C2-6-alkenylene, or C2-6-alkynylene, M represents single bond or C1-6-al ...


6
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it. Eisai R&D Management, Birch Stewart Kolasch & Birch, March 30, 2010: US07687664 (1 worldwide citation)

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula (I): ...


7
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Sakai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Safakazu Miyashita, Taro Hihara, Hitoshi Harada, Kaya Ohashi: Carboxylic acid derivative and salt thereof. Birch Stewart Kolasch & Birch, May 27, 2004: US20040102634-A1

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


8
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Benzene compound and salt thereof. Birch Stewart Kolasch & Birch, July 15, 2004: US20040138271-A1

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hyd ...


9
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Carboxylic acid derivative and medicine comprising salt or ester of the same. Birch Stewart Kolasch & Birch, October 28, 2004: US20040214888-A1

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula: 1 ( ...


10
Richard Clark, Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Cyclic compound and ppar agonist. Birch Stewart Kolasch & Birch, January 20, 2005: US20050014833-A1

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each re ...