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Van, Acker Koenraad Lodewijk August, Bunkens Lieve Elisabeth Louis, Dams Géry Karel Julia, Hertogs Kurt, Ivens Tania Pauline Eduard, Nijs Erik Jos Amandus: Time-of-addition assay for identifying anti-viral compounds. Tibotec Pharmaceuticals, Van, Acker Koenraad Lodewijk August, Bunkens Lieve Elisabeth Louis, Dams Géry Karel Julia, Hertogs Kurt, Ivens Tania Pauline Eduard, Nijs Erik Jos Amandus, DAELEMANS Frank, March 31, 2005: WO/2005/028669 (4 worldwide citation)

The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an ass ...


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Simmen Kenneth Alan, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Surleraux Dominique Louis Nestor Ghislain, Dams Géry Karel Julia, Quirynen Ludo Maria Marcel, Hertogs Kurt, Pauwels Rudi Wilfried Jan: Hcv inhibitiing sulfonamides. Tibotec Pharmaceuticals, Simmen Kenneth Alan, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Surleraux Dominique Louis Nestor Ghislain, Dams Géry Karel Julia, Quirynen Ludo Maria Marcel, Hertogs Kurt, Pauwels Rudi Wilfried Jan, DAELEMANS Frank, April 7, 2005: WO/2005/030194 (2 worldwide citation)

The present invention concerns sulfonamide derivatives having the general formula (I) and N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs and esters thereof, wherein Q1 is -S- or -O-; R1 is hydrogen, C1-6alkyl, hydroxy, amino, halogen, aminoC1-4alkyl and mono-or di(C1-4 alkyl)amino ...


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Hertogs Kurt, Larder Brendan, Pauwels Rudi Wilfried Jan: New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance. Virco, March 13, 2002: EP1185712-A1 (1 worldwide citation)

The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target populati ...


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Larder Brendan, Bloor Stuart, Hertogs Kurt, Dehertogh Pascale Alfons Rosa, Mortier Rudy Jean Marc: Methods for measuring drug resistance against hcv. Virco Bvba, January 7, 2009: EP2011889-A1

The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or ...


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