1
Dieter Reinscheid, Bernhard Eikmanns, Hermann Sahm: DNA which regulates gene expression in coryneform bacteria. Forschungszentrum Julich, Herbert Dubno, Jonathan Myers, October 12, 1999: US05965391 (28 worldwide citation)

The invention concerns a DNA fragment located in front of the malate synthase gene of a coryne-form bacterium and isolated from the latter. Any structural gene which codes for a protein can be inserted after this DNA fragment. After transformation of such a construct into a coryne-form bacterium, ex ...


2
Lothar Eggeling, Georg Thierbach, Hermann Sahm: Method for the fermentative production of D-pantothenic acid using Coryneform bacteria. Degussa Huls Aktiengesellschaft, Forschunszentrum Julich, Pillsbury Madison & Sutro, January 23, 2001: US06177264 (27 worldwide citation)

The invention discloses three polynucleotide sequences for the fermentative production of D-pantothenic acid. These polynucleotide sequences are genes named panB, encoding a ketopantoate hydroxymethyltransferase, panC, encoding pantothenate synthase, and ilvD, encoding dihydroxy-acid dehydratase. Th ...


3
Robert Klemps, Siegfried Schoberth, Hermann Sahm, Werner Swyzen: Process for the microbial anaerobic production of acetic acid. Kernforschungsanlage Juelich, Pfeifer Langen, Foley & Lardner Schwartz Jeffery Schwaab Mack Blumenthal & Evans, June 19, 1990: US04935360 (22 worldwide citation)

An anaerobic production of acetic acid by fermentation can employ homoacetogenic bacteria in an aqueous solution of fermentable substrates, especially sugar, with the result of increased acetic-acid concentrations (over 3%), when the substrate solution initially used in the fermentation already cont ...


4
Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfeffere, Lothar Eggeling, Hermann Sahm, Miroslav Patek: L-lysine-producing corynebacteria and process for the preparation of l-lysine. Degussa Huls Aktiengesellschaft, Pillsbury Madison & Sutro, March 13, 2001: US06200785 (21 worldwide citation)

The invention relates to L-lysine-producing strains of corynebacteria with amplified lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dih ...


5
Lothar Eggeling, Hermann Sahm: Method for microbially producing L-valine. Forschungszentrum Julich, Connolly Bove Lodge & Hutz, December 15, 2009: US07632663 (17 worldwide citation)

The present invention relates to a process for the microbial production of L-valine in which the dihydroxy acid-synthase (ilvD) activity and/or the ilvD gene expression is intensified in a microorganism. As an alternative or in combination with this, the acetohydroxy acid-synthase (ilvBN) activity a ...


6
Stephanie Bringer Meyer, Hermann Sahm: Process for obtaining sorbitol and gluconic acid by fermentation, and cell material suitable for this purpose. Forschungszentrum Juelich, Foley & Lardner, May 21, 1991: US05017485 (14 worldwide citation)

A process is disclosed for obtaining sorbitol and gluconic acid, or gluconate, by fermentation in aqueous glucose/fructose mixtures. Zymomonas mobilis cells are used which have been permeabilized by the freeze technique and which have preferably been obtained by freezing cell centrifugates of pH 6 t ...


7
Caroline Kreutzer, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek: L-lysine-producing corynebacteria and process for the preparation of lysine. Degussa, Pillsbury Winthrop, March 1, 2005: US06861246 (13 worldwide citation)

The invention relates to L-lysine-producing strains of corynebacteria with enhanced pyc gene (pyruvate carboxylase gene), in which strains additional genes, chosen from the group consisting of the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the lysE gene (ly ...


8
Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek: L-lysine-producing corynebacteria and process for the preparation of L-lysine. Dégussa Hüls Aktiengesellschaft, Forschungszentrum Jülich, Pillsbury Winthrop, June 8, 2004: US06746855 (13 worldwide citation)

The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihy ...


9
Marina Vrlijc, Lothar Eggeling, Hermann Sahm: Process for the microbial production of amino acids by boosted activity of export carriers. Forschungszentrum Jülich, Klaus J Bach, February 22, 2005: US06858406 (11 worldwide citation)

The invention pertains to a process for the microbial production of amino acids. The process involves boosting the export carrier activity and/or export gene expression of a microorganism which produces the desired amino acid. It was found that a single specific gene is responsible for the export of ...


10
Lothar Eggeling, Manfred Paschke, Hermann Sahm: Process for the microbial production of alcoholoxidase. Kernforschungsanlage Julich Gesellschaft m b H, Karl F Ross, February 10, 1981: US04250261 (10 worldwide citation)

A method of producing alcohol oxidase wherein Hansenula polymorpha yeast is cultivated in a nutrient broth containing inorganic nutrient salts of which either the phosphate, nitrate or potassium is present in a cell-growth-limiting concentration at a temperature of 25.degree. to 45.degree. C. and a ...