1
Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon W M M Terstappen, Shawn Mark O Hara, Steven Gross: Analysis of circulating tumor cells, fragments, and debris. Veridex, January 4, 2011: US07863012 (36 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotterĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown ...


2
Herman Rutner, Thomas F Dodd: Preparation of solid substrate containing receptor and labeled form of ligand for assays. Becton Dickinson and Company, Louis E Marn, Elliot M Olstein, March 17, 1981: US04256725 (36 worldwide citation)

A solid substrate is simultaneously contacted with a labeled form of a ligand to be assayed, a receptor for the ligand to be assayed and a solution of an ionic salt to produce a solid substrate which contains the labeled form of the ligand and the receptor. In a subsequent assay for the ligand, the ...


3
Galla Chandra Rao, Herman Rutner: Labeled cell sets for use as functional controls in rare cell detection assays. Immunivest Corporation, Joseph F Aceto Esq, James L Wilcox Esq, October 16, 2007: US07282350 (27 worldwide citation)

Methods and kits for used as an internal or external control in rare cell analysis are disclosed. A plurality of fluorescently distinct sets of cells is used to define a range to assess the isolation of rare target cells from a sample. Thus, a known number of cells, expressing the surface and intrac ...


4
Herman Rutner, Thomas F Dodd: Method for non-covalent coating of antibodies on solid substrates. Becton Dickinson and Company, Louis E Marn, Elliot M Olstein, March 17, 1981: US04256724 (17 worldwide citation)

Antibodies to lipophilic haptens and antigens, such as the antibodies of bile acids are non-covalently coated on a solid substrate for use in solid phase immunoassays by including in the antibody coating solution an inorganic salt, such as ammonium sulfate, to increase the ionic strength of the solu ...


5
Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon W M M Terstappen, Shawn Mark O Hara, Steven Gross: Analysis of circulating tumor cells, fragments, and debris. Veridex, Ruby T Hope, December 11, 2012: US08329422 (14 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTERĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown ...


6
Herman Rutner, Josephine D Readio, Leslie Oppenheimer: Surface modified liposomes. Becton Dickinson and Company, Richard E Brown, September 28, 1993: US05248590 (10 worldwide citation)

A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants are enzymes or dyes. In the most preferred r ...


7
Anandrao S Akerkar, Herman Rutner: Radiolabeled derivatives of folic acid. Becton Dickinson and Company, Louis E Marn, Elliot M Olstein, June 30, 1981: US04276280 (9 worldwide citation)

Derivatives of folic acid wherein the .alpha.-carboxyl group of the glutamyl moiety is substituted with a radical which is capable of being radioiodinated, such as, substituted and unsubstituted tyrosyl and histidyl. The radioiodinated derivatives can be employed as tracers for the assay of folates.


8
Anandrao S Akerkar, Herman Rutner: Monoradioiodinated derivatives and precursors for production thereon. Becton Dickinson & Company, Louis E Marn, Elliot M Olstein, May 13, 1980: US04202874 (6 worldwide citation)

Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic or imidazole substituent group in which one of the possible two sites on the group for radioiodination is substituted to permit p ...


9
Herman Rutner, Raul Rapun, Nathan Lewin: Derivatives of digoxigenin. Becton Dickinson & Company, Marn & Jangarathis, April 27, 1976: US03953431 (5 worldwide citation)

Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1##


10
Anandrao S Akerkar, Herman Rutner: Monoradioiodinated phenolic esters, acids and amines. Becton Dickinson & Company, Marn & Jangarathis, October 17, 1978: US04120867 (4 worldwide citation)

Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic or imidazole substituent group in which one of the possible two sites on the group for radioiodination is substituted to permit p ...