1
Lawrence C Creemer, Herbert A Kirst: Stereochemical Wortmannin derivatives. Eli Lilly and Company, Thomas J Dodd, David E Boone, January 2, 1996: US05480906 (55 worldwide citation)

This invention relates to derivatives of Wortmannin and particularly to 11,17 substituted derivatives of Wortmannin. The invention also relates to a method of using these compounds as PI-3-kinase inhibitors and as anti-tumor agents.


2
Manuel Debono, Herbert A Kirst: C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics. Eli Lilly and Company, Nancy J Harrison, Leroy Whitaker, April 11, 1989: US04820695 (34 worldwide citation)

C-20-Dihydro-deoxy-(cyclic amino)-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species, and pharmaceuti ...


3
Jon S Mynderse, James W Martin, Jan R Turner, Lawrence C Creemer, Herbert A Kirst, Mary C Broughton, Mary L B Huber: A83543 compounds and processes for production thereof. DowElanco, James P Leeds, Thomas D Zindrick, Kenneth L Loertscher, April 13, 1993: US05202242 (29 worldwide citation)

New fermentation products A83543L, A83543M, and A83543N, N-demethyl derivatives thereof, and salts thereof, are useful for the control of insects. A83543PsaL1 is useful for the preparation of A83543 components. Methods for making A83543J, A83543L, A83543M, and A83543N by culture of Saccharopolyspora ...


4
Carl Vincent DeAmicis, Peter Biagio Anzeveno, Jacek G Martynow, Kevin L McLaren, Frederick Richard Green III, Thomas C Sparks, Herbert A Kirst, Lawrence Camillo Creemer, Thomas V Worden, Joe Raymond Schoonover Jr, James Michael Gifford, Christopher J Hatton, Vidyadhar B Hegde, Gary D Crouse, Brian R Thoreen, Michael J Ricks: Synthetic modification of Spinosyn compounds. Dow AgroSciences, Donald R Stuart, Andrea T Borucki, December 14, 1999: US06001981 (26 worldwide citation)

The compounds of the present invention are prepared directly or indirectly by modifying the compounds that are naturally produced from Saccharopolyspora spinosa. The compounds of the invention have been shown to have activity against insects and mites. The compounds are prepared by modifying the rha ...


5
Herbert A Kirst, Karl H Michel: Antibiotic A10255 complex and factors, and process and production therefor. Eli Lilly and Company, Steven A Fontana, Leroy Whitaker, Nancy J Harrison, July 20, 1993: US05229362 (19 worldwide citation)

Newly-discovered antibiotic A10255 factors B, C, E, F, G, H, and J are produced by submerged aerobic fermentation of Streptomyces gardneri NRRL 15537 and NRRL 18260 or an A10255-producing variant or mutant thereof. The antibiotics are active against a wide variety of pathogenic bacteria, and also en ...


6
Jon S Mynderse, James A Mabe, Jan R Turner, Mary L B Huber, Mary C Broughton, Walter M Nakatsukasa, Lawrence Creemer, Herbert A Kirst, James W Martin: A83543 compounds and process for production thereof. DowElanco, Andrea T Borucki, September 23, 1997: US05670486 (17 worldwide citation)

New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A ...


7
Jon S Mynderse, James A Mabe, Jan R Turner, Mary L B Huber, Mary C Broughton, Walter M Nakatsukasa, Lawrence Creemer, Herbert A Kirst, James W Martin: A83543 compounds and process for production thereof. DowElanco, Andrea T Borucki, September 23, 1997: US05670364 (17 worldwide citation)

New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A ...


8
Jaswant S Gidda, Herbert A Kirst, David W Robertson: Method for treating gastrointestinal disorders. Eli Lilly and Company, Nancy J Harrison, Leroy Whitaker, April 24, 1990: US04920102 (17 worldwide citation)

Novel ring-contracted macrolides which enhance gastrointestinal motility and novel methods and compositions for treating gtastrointestinal disorders in animals with these macrolides and with certain other previously known ring-contracted macrolides are provided.


9
Mary C Broughton, Lawrence Creemer, Mary L B Huber, Herbert A Kirst, Jan R Turner: A83543 aglycones and pseudoglycones. DowElanco, Andrea T Borucki, July 23, 1996: US05539089 (14 worldwide citation)

A83543 Aglycones A83543AgA, A83543AgD, A83543AgE, and A83543AgF, and A83543 pseudoaglycones A83543PsaA2, A83543PsaB2, A83543PsaD2, and A83543PsaN2 are intermediates useful in preparation of known insecticides.


10
Jon S Mynderse, Mary C Broughton, Walter M Nakatsukasa, James A Mabe, Jan R Turner, Lawrence Creemer, Mary L B Huber, Herbert A Kirst, James W Martin: A83543 compounds and process for production thereof. DowElanco, Andrea T Borucki, November 24, 1998: US05840861 (13 worldwide citation)

New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A ...



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