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Pramila A Bhatia, Jerome F Daanen, Ahmed A Hakeem, Teodozyj Kolasa, Mark A Matulenko, Kathleen H Mortell, Meena V Patel, Andrew O Stewart, Xueqing Wang, Zhiren Xia, Henry Q Zhang: Abbott Laboratories, Andreas M Danckers, May 5, 2009: US07528134 (15 worldwide citation)

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.


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Lee D Arnold, J├╝rgen Dinges, Richard W Dixon, Stevan W Djuric, Anna M Ericsson, Kimba Fischer, Alan F Gasiecki, Vijaya J Gracias, James H Holms, Makoto Takeshita, Michael R Michaelides, Melanie A Muckey, Paul Rafferty, Douglas H Steinman, Carol K Wada, Zhiren Xia, Irini Akritopoulou Zanze, Henry Q Zhang: Tricyclic pyrazole kinase inhibitors. Abbott Laboratories, B Gregory Donner, December 23, 2008: US07468371 (2 worldwide citation)

Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.


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Robert B Diebold, Stevan W Djuric, Vincent L Giranda, Laura A Hexamer, Nan Horng Lin, Julie M Miyashiro, Thomas D Penning, Magdalena Przytulinska, Thomas J Sowin, Gerard M Sullivan, Zhi Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W Woods, Zhiren Xia, Henry Q Zhang: Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases. Abbott Laboratories, Susan L Steele, Gregory B Donner, Gregory W Steele, June 7, 2011: US07956185 (2 worldwide citation)

Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.


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Richard B Silverman, Hui Huang, Henry Q Zhang: Inhibition of nitric oxide synthase by amino acids and dipeptides. Northwestern University, Leydig Voit & Mayer, August 14, 2001: US06274557 (1 worldwide citation)

Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide analogs that contain nitroarginine or another unnatural amino acid. Compositions can be used to selectiv ...