1
Lisa J Garrard, Dennis J Henner, Steven Bass, Ronald Greene, Henry B Lowman, James A Wells, David J Matthews: Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants. Genentech, Daryl B Winter, Walter H Dreger, May 12, 1998: US05750373 (348 worldwide citation)

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat pro ...


2
Lisa J Garrard, Dennis J Henner, Steven Bass, Ronald Greene, Henry B Lowman, James A Wells, David J Matthews: Monovalent phage display. Genentech, Daryl B Winter, Timothy R Schwartz, October 13, 1998: US05821047 (325 worldwide citation)

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat pro ...


3
Brian C Cunningham, Henry B Lowman, James A Wells, Ross G Clark, Kenneth Olson, Germaine G Fuh: Human growth hormone variants. Genentech, Merchant Gould Smith Edell Welter & Schmidt, December 15, 1998: US05849535 (146 worldwide citation)

Human growth hormone variants, DNA encoding the variants, vectors, host cells, pegylated forms of the variants, as well as methods of making the variants are disclosed.


4
Brian C Cunningham, Henry B Lowman, James A Wells, Ross G Clark, Kenneth Olson, Germaine G Fuh: Method for inhibiting growth hormone action. Genentech, Gates & Cooper, May 2, 2000: US06057292 (95 worldwide citation)

Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.


5
Henry B Lowman, Leonard G Presta, Paula M Jardieu, John Lowe: Anti-IgE antibodies and methods of improving polypeptides. Genentech, Craig G Svoboda, November 30, 1999: US05994511 (82 worldwide citation)

The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting muta ...


6
Steven H Bass, Ronald Greene, Henry B Lowman, James A Wells: Growth hormone variants with altered binding properties. Genentech, Laura Terlizzi, Emily M Haliday, Skjerven Morrill MacPherson Franklin and Friel, November 18, 1997: US05688666 (78 worldwide citation)

A method for selecting novel proteins such as growth hormone variants having altered binding properties for a growth hormone receptor molecule is provided. The method comprises fusing a gene encoding a hormone to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. ...


7
Manuel Baca, James A Wells, Leonard G Presta, Henry B Lowman, Yvonne Man yee Chen: Anti-VEGF antibodies. Genentech, Steven X Cui, Genentech, June 13, 2006: US07060269 (63 worldwide citation)

Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.


8
Lisa J Garrard, Dennis J Henner, Steven Bass, Ronald Greene, Henry B Lowman, James A Wells, David J Matthews: Enrichment method for variant proteins with altered binding properties. Genentech, Daryl B Winter, Timothy R Schwartz, March 21, 2000: US06040136 (49 worldwide citation)

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat pro ...


9
Henry B Lowman, James A Wells: Human growth hormone variants. Genentech, Daryl B Winter, Timothy R Schwartz, November 10, 1998: US05834598 (45 worldwide citation)

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat pro ...


10
Camellia W Adams, Andrew C Chan, Craig W Crowley, Henry B Lowman, Gerald R Nakamura, Leonard G Presta: Immunoglobulin variants and uses thereof. Genentech, Morrison & Foerster, September 21, 2010: US07799900 (39 worldwide citation)

The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.