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Bender Steven Lee, Broka Chris Allen, Campbell Jeffrey Allen, Castelhano Arlindo Lucas, Fisher Lawrence Emerson, Hendricks Robert Than, Sarma Keshab: Matrix metalloprotease inhibitors. Hoffmann La Roche, Agouron Pharma, June 25, 1997: EP0780386-A1 (167 worldwide citation)

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocy ...


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HENDRICKS ROBERT THAN: Pyrrolopyrazine kinase inhibitors. F HOFFMANN LA ROCHE, Salud Carlos, September 29, 2011: WO/2011/117145 (25 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables n, p, q, Q, X, X' and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


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Du Bois Daisy Joe, Elworthy Todd Richard, Hendricks Robert Than, Kondru Rama K, Lou Yan, Owens Timothy D, Park Jaehyeon, Smith David Bernard, Soth Michael, Yang Hanbiao: Pyrrolopyrazine kinase inhibitors. F Hoffmann La Roche, Du Bois Daisy Joe, Elworthy Todd Richard, Hendricks Robert Than, Kondru Rama K, Lou Yan, Owens Timothy D, Park Jaehyeon, Smith David Bernard, Soth Michael, Yang Hanbiao, HEIROTH Ulrike, September 3, 2009: WO/2009/106443 (5 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


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Du Bois Daisy Joe, Elworthy Todd Richard, Hendricks Robert Than, Hermann Johannes Cornelius, Kondru Rama K, Lou Yan, Owens Timothy D, Park Jaehyeon, Smith David Bernard, Soth Michael: Pyrrolopyrazine kinase inhibitors. F Hoffmann La Roche, Du Bois Daisy Joe, Elworthy Todd Richard, Hendricks Robert Than, Hermann Johannes Cornelius, Kondru Rama K, Lou Yan, Owens Timothy D, Park Jaehyeon, Smith David Bernard, Soth Michael, HEIROTH Ulrike, September 3, 2009: WO/2009/106444 (5 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


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Hendricks Robert Than, Humphreys Eric Roy, Martin Joseph Armstrong, Prince Anthony, Sarma Keshab: Antiviral nucleoside derivatives. F Hoffmann La Roche, RAUBER Beat, June 24, 2004: WO/2004/052905 (4 worldwide citation)

The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula (I) and (II), pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said ...