1
Helmut Wahlig, Elvira Dingeldain, Dietrich Braun: Medicinally useful, shaped mass of collagen resorbable in the body. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, August 31, 1982: US04347234 (185 worldwide citation)

A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.


2
Helmut Wahlig, Elvira Dingeldein, Edgar Wüst, Christoph Sattig: Resorbable bone implant material and method for producing the same. Coripharm Medizinprodukte & Co KG, Norris McLaughlin & Marcus, February 10, 2004: US06689375 (126 worldwide citation)

The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically prepared, precipitated crystalline nanoparticles of high purity, which have a crystal size of 10-20 nm ...


3
Helmut Wahlig, Elvira Dingeldein, Dietrich Braun: Medicinally useful, shaped mass of collagen resorbable in the body. Merck Patent Gesellschaft Mit Beschrankter Haftung, Millen & White, September 22, 1981: US04291013 (124 worldwide citation)

A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.


4
Werner Rogalski, Richard Kirchlechner, Jurgen Seubert, Rudolf Gottschlich, Rosmarie Steinigeweg, Rolf Bergmann, Helmut Wahlig, Joachim Gante: Tetracyclic compounds. Merck Patent Gesellschaft mit beschrankter Haftung, Millen & White, May 17, 1977: US04024272 (104 worldwide citation)

Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in eac ...


5
Berthold Nies, Elvira Dingeldein, Helmut Wahlig: Bone replacement material with FGF. Merck Patent Gesellschaft mit Beschrankter Haftung, Millen White Zelano & Branigan P C, September 12, 2000: US06118043 (95 worldwide citation)

The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.


6
Hans Jorg Bauer, Gerd Bauer, Elvira Dingeldein, Helmut Wahlig: Implant material. Merck Patent Gesellschaft mit beschrankter Haftung, Millen White Zelano & Branigan, August 16, 1994: US05338772 (68 worldwide citation)

The invention relates to an implant material which is based on a composite material of calcium phosphate ceramic particles and bioabsorbable polymer, in which the proportion of calcium phosphate ceramic particles is at least 50% by weight and the particles are joined to one another by polymer bridge ...


7
Klaus Draenert, Helmut Wahlig: Multi-component material and process for its preparation. Klaus Draenert, Kinney & Lange P A, June 27, 2000: US06080801 (67 worldwide citation)

A multiple component material, in particular a filler particle containing implantation material is produced and used to anchor prothesis components in bones, to strengthen bones, as dowel for bone screws and as implants for anchoring screws. The polymer component of the disclosed implantation materi ...


8
Elvira Dingeldein, Helmut Wahlig, Manfred Wotschokowsky, Gu Moddelmog: Tricalcium phosphate for implant materials wherein the pores of the tricalciumphosphate are filled with antibiotic and amino acid. Merck Patent Gesellschaft Mit Beschrankter Haftung, Millen White & Zelano, September 26, 1989: US04869906 (56 worldwide citation)

A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.


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Helmut Wahlig, Elvira Dingeldein, Christoph Sattig, Edgar Wüst: Preparation and application device for materials to be prepared as a paste-like flowable mass, especially bone cement. Coripharm Medizinprodukte & Co KG, Norris McLaughlin & Marcus P A, June 29, 2004: US06755563 (41 worldwide citation)

The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be m ...