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Helen T Lee, Joseph A Picard, Drago R Sliskovic, Wendell Wierenga: N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents. Warner Lambert Company, Elizabeth M Anderson, May 27, 1997: US05633287 (28 worldwide citation)

The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein X and Y are oxygen, sulfur, or (CR'R").sub.n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R.sub.1 and R.sub. ...


2
Helen T Lee, Joseph A Picard, Drago R Sliskovic, Wendell Wierenga: N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents. Warner Lambert Company, Elizabeth M Anderson, February 13, 1996: US05491172 (24 worldwide citation)

The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein X and Y are oxygen, sulfur, or (CR'R").sub.n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R.sub.1 and R.sub. ...


3
Helen T Lee, Joseph A Picard, Drago R Sliskovic: Sulfonate ACAT inhibitors. Warner Lambert Company, Charles W Ashbrook, Todd M Crissey, April 23, 1996: US05510379 (20 worldwide citation)

.beta.-Carboxy sulfonates of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is -O-, -S-, or -NR.sub.2 -, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hyperchol ...


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Helen T Lee, Patrick M O Brien, Joseph A Picard, Claude F Purchase Jr, Bruce D Roth, Drago R Sliskovic, Andrew D White: Isoxazolyl-substituted alkyl amide ACAT inhibitors. Warner Lambert Company, Michael J Atkins, Charles W Ashbrook, November 22, 1994: US05366987 (11 worldwide citation)

Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 =R.sub.3 =H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having ...


6
Helen T Lee, Joseph A Picard, Drago R Sliskovic: .beta.-carboxy sulfonamide ACAT inhibitors. Warner Lambert Company, Charles W Ashbrook, February 13, 1996: US05491170 (7 worldwide citation)

.beta.-Carboxy sulfonyl compounds of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 is hydrogen or alkyl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is --O--, --S--, or --NR.sub.2 --, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT ...


7
Helen T Lee, Patrick M O Brien, Joseph A Picard, Claude F Purchase Jr, Bruce D Roth, Drago R Sliskovic, Andrew D White: Pyrazolo-substituted alkyl amide acat inhibitors. Warner Lambert Company, Charles W Ashbrook, August 15, 1995: US05441975 (4 worldwide citation)

Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 =R.sub.3 =H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having ...


8
Helen T Lee, Drago R Sliskovic: Sulfonamide tetrazole ACAT inhibitors. Warner Lambert Company, Ronald A Daignault, August 24, 1993: US05239082 (1 worldwide citation)

Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from 1 to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, fluoro, alkyl, al ...


9
Helen T Lee, Joseph A Picard, Drago R Sliskovic: Iminodicarbonic, iminodicarbonodithioic, and thiocarbonylcarbamic acid esters useful as ACAT inhibitors. Warner Lambert Company, Ronald A Daignault, February 23, 1993: US05189058

The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R.sub.1 and R.sub.2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, aralkyl, a hydrocarbon chain, a hetero group, or a heteroalkyl gr ...


10
Helen T Lee, Joseph A Picard, Drago R Sliskovic: Biurets, aminocarbonyl carbamates, and aminocarbonyl thiocarbamates useful as ACAT inhibitors. Warner Lambert Company, Ruth H Newtson, October 6, 1992: US05153223

Novel compounds useful as ACAT inhibitors having the formula ##STR1## wherein Q is R.sub.5 O; R.sub.5 S-- or NR.sub.3 R.sub.4 ; wherein R is hydrogen or alkyl C.sub.1 -C.sub.20 or --CH.sub.2 Ph; wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, a hydrocarbon chain aralkyl, phenyl or substi ...