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Andries Koenraad Jozef L M, Corte Bart de, Jonge Marc Rene de, Heeres Jan, Ho Chih Yung, Janssen Marcel August Constant, Janssen Paul Adriaan Jan, Koymans Lucien Maria Henricus, Kukla Michael Joseph, Ludovici Donald William, Aken Koen Jeanne Alfons Van: Hiv inhibiting pyrimidine derivatives. Janssen Pharmaceutica, September 29, 1999: EP0945443-A1 (86 worldwide citation)

This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR or N; n is 0 to 4; Q is hydrogen or -NRR; R and R are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkylo ...


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Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Janssen Paul Adriaan Jan: Hiv inhibiting bicyclic pyrimidine derivatives. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Arts Frank Xavier Jozef Herwig, WANTE Dirk, May 4, 2006: WO/2006/045828 (46 worldwide citation)

HIV replication inhibitors of formula (I) N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a1=a2-a3=a4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH- CH=N-, -N=N-CH=CH-; -b1=b2-b3=b4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, ...


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Kukla Michael Joseph R, Ludovici Donald W, Janssen Paul Adriaan Jan, Heeres Jan, Moereels Henri Emiel Lodewijk: Substituted diamino-1,3,5-triazine derivatives. Janssen Pharmaceutica, April 8, 1998: EP0834507-A1 (40 worldwide citation)

This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R and R are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6 ...


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Heeres Jan, Backx Leo J J, Mostmans Joseph H: 1-(.beta.-Aryl-.beta.-R-ethyl)imidazoles. Janssen Pharmaceutica, Conte Salvatore R, December 16, 1975: US3927017 (24 worldwide citation)

Compounds of the class of 1-(.beta.-aryl-.beta.-R-ethyl)imidazoles, useful as antibacterial and antifungal agents.


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Van Wauwe Jean Pierre Frans, Heeres Jan, Backx Leo Jacobus Jozef: 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols.. Janssen Pharmaceutica, September 6, 1989: EP0331232-A2 (21 worldwide citation)

5-Lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols having the formula wherein R and R each independently are hydrogen, C1-6alkyl or halo; R and R each independently are hydrogen, halo, amino, nitro or trifluoromethyl; Y is a heterocyclic radical of formula for use as a medicine. Composition ...


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Heeres Jan, Stokbroekx Raymond A, Backx Leo J J: ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles.. Janssen Pharmaceutica, September 12, 1984: EP0118138-A1 (18 worldwide citation)

Novel chemical compounds of the formula and intermediate compounds of the formula and their pharmaceutically acceptable acid addition salts and stereochemically isomeric forms, which compounds and intermediate compounds are useful as anti-microbial agents; pharmaceutical compositions containing such ...