1
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 17, 1996: US05585089 (1552 worldwide citation)

Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunog ...


2
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, June 25, 1996: US05530101 (1356 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


3
Cary L Queen, Man Sung Co, William P Schneider, Nicholas F Landolfi, Kathleen L Coelingh, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend & Townsend & Crew, December 2, 1997: US05693762 (1197 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


4
Cary L Queen, Harold E Selick: Humanized immunoglobulins and methods of making the same. Protein Design Labs, Townsend and Townsend and Crew, January 30, 2001: US06180370 (811 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized i ...


5
Cary L Queen, William P Schneider, Harold E Selick: Polynucleotides encoding improved humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 2, 1997: US05693761 (692 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


6
Ron L Hale, Amy Lu, Dennis Solas, Harold E Selick, Kevin R Oldenburg, Alejandro C Zaffaroni: Compositions and methods for enhanced drug delivery. Affymax Technologies, Lauren L Stevens, March 4, 1997: US05607691 (158 worldwide citation)

The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and de ...


7
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, April 4, 2006: US07022500 (57 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


8
David A Campbell, Valery V Antonenko, Harold E Selick, Robert M Gavin, Satoru Ida, Arthur H Muir: System and method for solid-phase parallel synthesis of a combinatorial collection of compounds. Glaxo Wellcome, Darin J Gibby, Lauren L Stevens, January 2, 2001: US06168914 (40 worldwide citation)

The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of middle plates, with each middle plate defining a plurality of reaction zones arranged in a two dimensional a ...


9
Robert M Gavin, Harold E Selick, Gregory A Smith: Split multi-well plate and methods. Glaxo Group, Darin Gibby, Lauren L Stevens, October 5, 1999: US05962250 (40 worldwide citation)

The invention provides exemplary testing devices, systems, and methods for evaluating the permeation of various chemicals through different types of cells. In one exemplary embodiment, a testing device is provided which comprises a plate defining at least one well having an open top end. At least on ...


10
David A Campbell, Valery V Antonenko, Harold E Selick: System and method for solid-phase parallel synthesis of a combinatorial collection of compounds. Glaxo Group, Darin J Gibby, Lauren L Stevens, July 4, 2000: US06083682 (29 worldwide citation)

The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of middle plates, with each middle plate defining a plurality of reaction zones arranged in a two dimensional a ...