1
Hardman Norman Dr, Gill Laura Lee Dr, de Winter Ronald F J Dr, Wagner Kathrin, Heusser Christoph Dr: Novel chimeric antibodies.. Ciba-Geigy, July 12, 1989: EP0323806-A1 (51 worldwide citation)

The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodie ...


2
Wels Winfried Stephan Dr, Hynes Nancy E Dr, Harwerth Ina Maria, Groner Bernd Dr, Hardman Norman Dr, Zwickl Markus: Recombinant antibodies specific for a growth factor receptor.. Ciba-Geigy, September 9, 1992: EP0502812-A1 (48 worldwide citation)

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manu ...


3
Mestan Juergen Dr, Lazdins Janis K Dr, Woods Cook Kathie A, Hardman Norman Dr, Hochkeppel Heinz Kurt Dr: Novel anti-hiv antibodies.. Ciba-Geigy, December 23, 1992: EP0519866-A1 (11 worldwide citation)

The invention concerns monoclonal antibodies and antibody derivatives directed against HIV core protein p24 which recognize p24 expressed on the surface of HIV-infected macrophages and/or kill HIV-infected cells. The monoclonal antibodies of the invention may be murine antibodies or chimeric antibod ...


4
Hardman Norman Dr: Chimeric antiidiotypic monoclonal antibodies.. Ciba-Geigy, August 12, 1992: EP0498767-A2 (6 worldwide citation)

The invention concerns chimeric antiidiotypic monoclonal antibodies consisting of human constant regions and murine variable regions of an antibody which recognizes antibodies directed against HLA class II antigens, and derivatives thereof which retain the specificity of the chimeric antibody from w ...


5
Hardman Norman Dr, Kolbinger Frank, Saldanha Jose: Reshaped monoclonal antibody against immunoglobulin isotype. Ciba-Geigy, Tanox Biosyst, August 16, 1994: JP1994-225788

PURPOSE: To obtain a reshaped human monoclonal antibody and to provide diagnosis, prophylaxis and treatment of allergy using the reshaped monoclonal antibody. CONSTITUTION: This reshaped human monoclonal antibody is directed against an isotypic determinant of an immunoglobulin E(IgE) and its derivat ...


6
Mestan Juergen Dr, Lazdins Janis K Dr, Woods Cook Kathie A, Hardman Norman Dr, Hochkeppel Heinz Kurt Dr: Novel anti-hiv antibody. Ciba-Geigy, October 26, 1993: JP1993-276988

PURPOSE: To obtain a novel monoclonal antibody useful for prevention of progress of AIDS, treatment of the AIDS and diagnosis of HIV infection in immunoassay. CONSTITUTION: This anti-HIV antibody is a monoclonal antibody recognizing HIV core protein P24 expressed on the surface of HIV-infected macro ...


7
Hardman Norman Dr: Novel chimeric antiidiotypic monoclonal antibody. Ciba-Geigy, November 9, 1993: JP1993-292994

PURPOSE: To obtain novel chimeric antiidiotypic monoclonal antibodies useful for regulating immune responses and treating autoimmune diseases. CONSTITUTION: A chimeric antiidiotypic monoclonal antibody consisting of murine variable regions and human constant regions of an antibody which recognizes a ...



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