1
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (62 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


2
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


3
Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Takashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, June 26, 2002: EP1216980-A1 (25 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the follow ...


4
Watanabe Mineo C O Mitsubishi, Harada Hitoshi C O Mitsubishi, Takemura Masanori C O Mitsubis: Method for manufacturing wafer.. Mitsubishi Materials, Mitsubishi Material Silicon, March 23, 1994: EP0588055-A2 (21 worldwide citation)

There is disclosed a wafer-manufacturing method in which a single crystal ingot is first sliced into a plurality of wafers, and both surfaces of each wafer are subjected to grinding or lapping operation. Then, the front and back surfaces of the wafer are subjected to etching. Thereafter, the back su ...


5
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, January 14, 2004: EP1380562-A1 (14 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


6
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


7
Harada Hitoshi, Asano Osamu, Ueda Masato, Miyazawa Shuhei, Kotake Yoshihiko, Kabasawa Yasuhiro, Yasuda Masahiro, Yasuda Nobuyuki, Iida Daisuke, Nagakawa Junichi, Hirota Kazuo, Nakagawa Makoto: Pyrimidine compound and medicinal composition thereof. Eisai, July 21, 2004: EP1439175-A1 (11 worldwide citation)

The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R and R are the same as ...


8
Harada Hitoshi, Asano Osamu, Miyazawa Shuhei, Ueda Masato, Yasuda Masahiro, Yasuda Nobuyuki: 2-aminopyridine compounds and use thereof as drugs. Eisai, May 7, 2003: EP1308441-A1 (10 worldwide citation)

The present invention provides 2-aminopyridine compound having an excellent adenosine receptor (A1, A2a, A2b receptors) antagonism, which is represented by the following formula: (wherein, R represents cyano group, carboxyl group or an optionally substituted carbamoyl group; R represents hydrogen at ...


9
Mima Hiroyuki, Torii Zenzo, Masuda Kenzo, Harada Hitoshi, Meguro Satoshi, Fujii Shigeo, Hatano Hiroyuki, Muto Kenji, Ifuku Toshihiro: Recording/reproducing separated magnetic head. Hitachi Metals, August 3, 2001: JP2001-209909 (5 worldwide citation)

PROBLEM TO BE SOLVED: To realize the miniaturization, the higher capacity and the higher transfer rate of a recording/reproducing separated magnetic head by narrowing track width, controlling the depth of a gap and enhancing heat radiation.SOLUTION: A recording head part is formed in the following s ...


10
Shimizu Yasuo, Nakamura Yoshito, Sueyoshi Shunichiro, Yoshimoto Nobuhiko, Kobayashi Koji, Fukuda Yuichi, Doi Mizuho, Harada Hitoshi, Hoshi Tomohiro: Magnetostrictive coat forming method. Honda Motor, November 17, 2004: EP1477788-A2 (4 worldwide citation)

For forming an annular magnetostrictive coat (16, 17) on an outer peripheral surface of a rotational shaft (11) associated with a magnetostrictive torque sensor, a magnetostrictive-coat forming method comprises a step of fitting a cylindrical masking jig (16, 17) over the outer peripheral surface of ...