1
Mark Deem, Hanson Gifford III, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Methods and apparatus for renal neuromodulation. Ardian, Perkins Coie, January 26, 2010: US07653438 (341 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


2
Denise Demarais, Benjamin J Clark, Nicolas Zadno, Erik Thai, Hanson Gifford III: Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach. Ardian, Perkins Coie, November 17, 2009: US07620451 (305 worldwide citation)

Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other c ...


3
Denise Demarals, Hanson Gifford III, Mark Deem, Howard R Levin, Mark Gelfand, Nicolas Zadno: Methods and apparatus for monopolar renal neuromodulation. Ardian, Perkins Coie, March 6, 2012: US08131371 (248 worldwide citation)

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or bl ...


4
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for catheter-based renal denervation. Ardian, Perkins Coie, April 3, 2012: US08150520 (230 worldwide citation)

Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or e ...


5
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for renal neuromodulation. Ardian, Perkins Coie, March 27, 2012: US08145317 (223 worldwide citation)

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusio ...


6
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods and apparatus for bilateral renal neuromodulation. Ardian, Perkins Coie, April 3, 2012: US08150519 (223 worldwide citation)

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or el ...


7
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for treating a condition or disease associated with cardio-renal function. Ardian, Perkins Coie, May 8, 2012: US08175711 (219 worldwide citation)

Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or ...


8
Denise Demarais, Benjamin J Clark, Nicolas Zadno, Erik Thai, Hanson Gifford III: Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach. Ardian, Perkins Coie, January 18, 2011: US07873417 (149 worldwide citation)

Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other c ...


9
Mark Deem, Denise Demarais, Douglas Sutton, Hanson Gifford III, Howard R Levin, Mark Gelfand, Benjamin J Clark: Methods and apparatus for renal neuromodulation. Ardian, Perkins Coie, March 27, 2012: US08145316 (138 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


10
Denise Demarais, Hanson Gifford III, Mark Deem, Nicolas Zadno, Benjamin J Clark, Andrew Wu, Kenneth J Michlitsch: Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen. Medtronic Ardian Luxembourg r l, January 8, 2013: US08347891 (131 worldwide citation)

Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first posit ...



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