1
Hans P Merkle, Klaus Nagels, Dietrich Schacht, Hans Michael Wolff: Active ingredient patch for low-melting and/or volatile active ingredients. Schwarz Pharma, Marshall O Toole Gerstein Murray & Borun, June 18, 1996: US05527536 (14 worldwide citation)

The invention concerns a patch for the controlled release of readily available volatile active substances to the skin, the patch comprising a back layer and, bonded to it, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive ...


2
Jurgen K Sandow, Rainer Schmiedel, Klaus Wirth, Hans P Merkle, Suzanne Raehs: Cyclic peptides as promoters of absorption on administration onto the mucosa. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett and Dunner, February 25, 1992: US05091365 (7 worldwide citation)

The invention relates to the use of aids of the general formula ##STR1## in which B denotes a basic amino acid, A/B denotes an acidic or basic amino acid, X denotes a neutral and hydrophilic amino acid, L denotes a lipophilic neutral amino acid, and R denotes hydrogen or an acyl radical, or the phys ...


3
Hans P Merkle, Klaus Nagels, Dietrich Schacht, Hans Michael Wolff: Active ingredient patch for low-melting and/or volatile active ingredients. Schwarz Pharma, Marshall O Toole Gerstein Murray & Borun, February 18, 1997: US05603948 (2 worldwide citation)

A method of preparing a patch for the controlled release of readily available volatile active substances to the skin is disclosed. The patch comprises a back layer, and, bonded to the back layer, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable fi ...


4
Bruno Gander, Giampietro Corradin, Ying Men, Claudio Thomasin, Hans P Merkle: Immunological response potentiation process. Burns Doane Swecker & Mathis L, April 11, 2002: US20020041879-A1

An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles, these antigen-loaded microparticles are dispersed in a biodegradable medium which triggers when it is par ...