1
Bruce W Worster, Dale E Crane, Hans J Hansen, Christopher R Fairley, Ken K Lee: Laser imaging system for inspection and analysis of sub-micron particles. Ultrapointe Corporation, Alan H MacPherson, Skjerven Morrill MacPherson Franklin & Friel, December 26, 1995: US05479252 (152 worldwide citation)

A laser imaging system is used to analyze defects on semiconductor wafers that have been detected by patterned wafer defect detecting systems (wafer scanners). The laser imaging system replaces optical microscope review stations now utilized in the semiconductor fab environment to examine detected o ...


2
Bruce W Worster, Dale E Crane, Hans J Hansen, Christopher R Fairley, Ken K Lee: Laser imaging system for inspection and analysis of sub-micron particles. Ultrapointe Corporation, Alan H MacPherson, Gary J Edwards, Skjerven Morrill MacPherson Franklin & Friel, October 5, 1999: US05963314 (127 worldwide citation)

A laser imaging system is used to analyze defects on semiconductor wafers that have been detected by patterned wafer defect detecting systems (wafer scanners). The laser imaging system replaces optical microscope review stations now utilized in the semiconductor fab environment to examine detected o ...


3
Hans J Hansen, Milton D Goldenberg: Detection and treatment of infectious and inflammatory lesions. Immunomedics, Bernhard D Saxe, May 15, 1990: US04925648 (126 worldwide citation)

A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said ...


4
Gary L Griffiths, Hans J Hansen: Targeted combination immunotherapy of cancer. Immunomedics, Foley & Lardner, June 20, 2000: US06077499 (120 worldwide citation)

The invention provides compositions, methods and kits for effecting therapy of a tumor in a patient. The compositions comprise (A) a first conjugate comprising a targeting moiety, a first member of a binding pair, and a first therapeutic agent, wherein the targeting moiety selectively binds to a mar ...


5
Hans J Hansen, Shui on Leung, Jerry Shevitz: Preparation and use of immunoconjugates. Immunomedics, Foley & Lardner, August 22, 1995: US05443953 (114 worldwide citation)

The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an ...


6
Hans J Hansen, Shui on Leung, Jerry Shevitz, Gary L Griffiths, Seregulam V Govindan: Preparation and use of immunoconjugates. Immunomedics, Foley & Lardner, June 3, 1997: US05635603 (90 worldwide citation)

The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an ...


7
Hans J Hansen, Shui on Leung, Zhengxing Qu, David M Goldenberg: Internalizing anti-CD74 antibodies and methods of use. Immunomedics, Faegre & Benson, Richard A Nakashima, December 25, 2007: US07312318 (89 worldwide citation)

The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B ...


8
Hans J Hansen, Kathryn L Armour: CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies. Immunomedics, Foley & Lardner, February 23, 1999: US05874540 (71 worldwide citation)

A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less im ...


9
David M Goldenberg, Hans J Hansen: Immunotherapy of autoimmune disorders using antibodies which target B-cells. Immunomedics, Faegre & Benson, July 11, 2006: US07074403 (70 worldwide citation)

Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produced recombinantly as fusion protei ...


10
Dan Shochat, Hans J Hansen, Robert S Wu: Method for radiolabeling proteins. Immunomedics, Foley & Lardner, October 29, 1991: US05061641 (62 worldwide citation)

A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydral groups on the protein as endogenous ligands and optionally using an exogenous ligand which binds tightly to the radiome ...