1
Todd Richard Elworthy, Robert Than Hendricks, Rama K Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. Roche Palo Alto, George W Johnston, Dennis P Tramaloni, Jennifer L Kisko, March 8, 2011: US07902197 (32 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


2
Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. Roche Palo Alto, George W Johnston, Dennis P Tramaloni, Jennifer L Kisko, May 10, 2011: US07939531 (32 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


3
Johan D Oslob, Robert S McDowell, Russell Johnson, Hanbiao Yang, Marc Evanchik, Cristiana A Zaharia, Haiying Cai, Lily W Hu: Heterocyclic modulators of lipid synthesis. 3 V Biosciences, October 28, 2014: US08871790 (5 worldwide citation)

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders includi ...


4
Joe Timothy Bamberg, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Alam Jahangir, Rama K Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, David Bernard Smith, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. Roche Palo Alto, George W Johnston, Dennis P Tramaloni, Jennifer Kisko, August 30, 2011: US08008298 (3 worldwide citation)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


5
Hanbiao Yang, Wieslaw Mieczyslaw Kazmierski, Christopher Joseph Aquino: Pyrrolidine and azetidine compounds as CCR5 antagonists. SmithKline Beecham Corporation, Bonnie L Deppenbrock, September 18, 2007: US07271172 (2 worldwide citation)

The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatme ...


6
Darryl David Dixon, Jonas Grina, John A Josey, James P Rizzi, Stephen T Schlachter, Eli M Wallace, Bin Wang, Paul Wehn, Rui Xu, Hanbiao Yang: Aryl ethers and uses thereof. PELOTON THERAPEUTICS, Wilson Sonsini Goodrich & Rosati, May 15, 2018: US09969689

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice ...


7
Paul Wehn, Hanbiao Yang: Tricyclic inhibitors of HIF-2-alpha and uses thereof. PELOTON THERAPEUTICS, Wilson Sonsini Goodrich & Rosati, October 24, 2017: US09796697

Compounds comprising a fused tricylic core that modulate HIF-2α activity, pharmaceutical compositions containing these chemical entities, and methods of using these chemical entities for treating diseases associated with HIF-2α activity are described herein.


8
Johan D Oslob, Robert S McDowell, Russell Johnson, Hanbiao Yang, Marc Evanchik, Cristiana A Zaharia, Haiying Cai, Lily W Hu, Allan S Wagman: Heterocyclic modulators of lipid synthesis. 3 V Biosciences, Cooley, August 21, 2018: US10053450

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compou ...


9
Johan D Oslob, Robert S McDowell, Russell Johnson, Hanbiao Yang, Marc Evanchik, Cristiana A Zaharia, Haiying Cai, Lily W Hu: Heterocyclic modulators of lipid synthesis. 3 V Biosciences, Cooley, J Dean Farmer, November 7, 2017: US09809591

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders includi ...


10
Johan D Oslob, Robert S McDowell, Russell Johnson, Hanbiao Yang, Marc Evanchik, Cristiana A Zaharia, Haiying Cai, Lily W Hu, Allan S Wagman: Heterocyclic modulators of lipid synthesis. 3 V Biosciences, Cooley, August 30, 2016: US09428502

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compou ...