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Antonin Holy, Hana Dvorakova, Erik Desire Alice DeClercq, Jan Marie Rene Balzarini: Antiretroviral enantiomeric nucleotide analogs. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, May 2, 2000: US06057305 (70 worldwide citation)

Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.


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Petr Alexander, Antonin Holy, Hana Dvorakova: (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-to luenesulfonyloxy-1-trimethylacetoxypropane, its preparation and use. Ceskoslovenska akademie ved, Notaro & Michalos, July 14, 1992: US05130427 (12 worldwide citation)

The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine ...


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Petr Alexander, Antonin Holy, Hana Dvorakova: (2R)-2-[di(2-propyl)phosphonyylmethoxy]-3-P-tolue nesulfonyloxy-1-trimethylacetoxypropane, its preparation and use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Max D Hensley, July 8, 1997: USRE035558

The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine ...


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