1
Egbertson Melissa S, Hartman George D, Halczenko Wasyl, Laswell William L: Novel fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478328-A1 (101 worldwide citation)

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.


2
Egbertson Melissa S, Laswell William L, Hartman George D, Duggan Mark E, Halczenko Wasyl: Novel sulfonamide fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478363-A2 (75 worldwide citation)

A series of non-peptide derivatives of generic formula I that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation. i


3
Inamine Edward S, Lee Ta Jyh, Houck David R, Hensens Otto D, Halczenko Wasyl, Hartman George G, Smith Robert L: Novel hmg-coa reductase inhibitors.. Merck & Co, January 7, 1988: EP0251625-A2 (22 worldwide citation)

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): r


4
Halczenko Wasyl, Hartman George, Pitzenberger Steven: Prodrugs of antihypercholesterolemic compounds.. Merck & Co, March 9, 1988: EP0259087-A2 (6 worldwide citation)

Prodrugs of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): are disclosed. x


5
Duggan Mark E, Halczenko Wasyl, Hartman George D: 7-substituted hmg-coa reductase inhibitors.. Merck & Co, March 6, 1991: EP0415488-A2 (5 worldwide citation)

Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): b


6
Hartman George D, Halczenko Wasyl: Fibrinogen receptor antagonists. Merck & Co, April 20, 1994: GB2271567-A (4 worldwide citation)

Novel compounds of the formula: wherein R, X and Y are as defined in the specification, exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.


7
Leroy Shephard Kenneth, Halczenko Wasyl, Gordon Brenner Daniel: Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof.. Merck & Co, June 27, 1979: EP0002512-A1 (3 worldwide citation)

Compounds of the formula wherein R1 and R2 are hydrogen, alkyl, alkenyl, phenylalkyl, cycloalkyl or cycloalkylalkyl, R is R1, phenyl or dialkylaminoalkyl, and R3 is hydrogen, halogen, alkoxy, trifluoromethylthio, cyano or carboxy, are useful as anti-auxiety agents, as muscle relaxants and in the tre ...


8
Askew Ben C, Coleman Paul J, Duggan Mark E, Halczenko Wasyl, Hartman George D, Hunt Cecilia, Hutchinson John H, Meissner Robert S, Patane Michael A, Smith Garry R, Wang Jiabing: Integrin receptor antagonists. Merck & Co, October 4, 2000: EP1040098-A1 (2 worldwide citation)

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha nu beta 3, alpha nu beta 5, and/or alpha nu beta 6 and are us ...


9
Baldwin John J, Halczenko Wasyl, Habecker Charles M, Hartman George D, Graham Samuel L, Schwam Harvey, Ponticello Gerald S, Shepard Kenneth L: Thiophene sulfonamide antiglaucoma agents.. Merck & Co, December 14, 1988: EP0295049-A2 (2 worldwide citation)

Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.


10
Hartman George D, Halczenko Wasyl: (benzoyl)Thiophene(or furan)-sulfonamide and derivatives thereof for the topical treatment of elevated intraocular pressures.. Merck & Co, May 25, 1988: EP0268396-A1 (2 worldwide citation)

4-(benzoyl)thiophene(or furan)-2-sulfonamide and derivatives thereof are useful for the topical treatment of elevated intraocular pressure.