A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
A series of non-peptide derivatives of generic formula I that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation. i
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): r
Prodrugs of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): are disclosed. x
Novel compounds of the formula: wherein R, X and Y are as defined in the specification, exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.
Compounds of the formula wherein R1 and R2 are hydrogen, alkyl, alkenyl, phenylalkyl, cycloalkyl or cycloalkylalkyl, R is R1, phenyl or dialkylaminoalkyl, and R3 is hydrogen, halogen, alkoxy, trifluoromethylthio, cyano or carboxy, are useful as anti-auxiety agents, as muscle relaxants and in the tre ...
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha nu beta 3, alpha nu beta 5, and/or alpha nu beta 6 and are us ...
Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.
4-(benzoyl)thiophene(or furan)-2-sulfonamide and derivatives thereof are useful for the topical treatment of elevated intraocular pressure.