1
Guillermo J Tearney, Brett E Bouma: Optical methods for tissue analysis. The General Hospital Corporation, Dorsey & Whitney, June 12, 2007: US07231243 (226 worldwide citation)

The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.


2
Milen Shishkov, Brett Eugene Bouma, Guillermo J Tearney: System and method for optical coherence imaging. The General Hospital Corporation, Dorsey & Whitney, April 29, 2008: US07366376 (216 worldwide citation)

Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical coopera ...


3
Johannes F de Boer, Guillermo J Tearney, Brett E Bouma: Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands. The General Hospital Corporation, Dorsey & Whitney, April 8, 2008: US07355716 (211 worldwide citation)

Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequen ...


4
Robert O Kenet, Barney J Kenet, Guillermo J Tearney: Digital optical visualization, enhancement, quantification, and classification of surface and subsurface features of body surfaces. Vanguard Imaging, Brian M Dingman, November 17, 1998: US05836872 (195 worldwide citation)

A method for monitoring a region of a body surface includes recording at a first time a first multispectral digital image of the surface including the region, recording at a subsequent time a subsequent multispectral digital image of the surface including the region, and comparing the first and the ...


5
Robert O Kenet, Barney J Kenet, Guillermo J Tearney: Apparatus and method for monitoring visually accessible surfaces of the body. Vanguard Imaging, Choate Hall & Stewart, May 14, 1991: US05016173 (186 worldwide citation)

This invention relates to an improved apparatus and method for in vivo monitoring of visually accessible surfaces of the body. The invention synthesizes methods of systems identification and computer vision to quantify and/or classify features of surface or subsurface anatomic, physiologic, or patho ...


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Guillermo J Tearney, Brett E Bouma, Robert H Webb: Confocal microscopy with multi-spectral encoding. The General Hospital Corporation, Thomas J Kowalski, Amy Leahy, FrommerLawrence&Haug, January 22, 2002: US06341036 (161 worldwide citation)

A scanning confocal microscopy system, especially useful for endoscopy with a flexible probe which is connected to the end of an optical fiber(


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Jing Tang, Guillermo J Tearney, Brett E Bouma, S Eric Ryan, Simon Furnish, Andres Zuluaga: Multi-path optical catheter. InfraReDx, Fish & Richardson P C, March 2, 2004: US06701181 (155 worldwide citation)

First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.


8
Robert O Kenet, Guillermo J Tearney: Apparatus and method for spatially positioning images. Vanguard Imaging, Joseph S Iandiorio, March 8, 1994: US05291889 (141 worldwide citation)

An apparatus and method for facilitating the positioning of a live image with respect to a reference image in which the live and reference images are combined to produce a composite image that is displayed.


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Seok Hyun Yun, Brett Eugene Bouma, Guillermo J Tearney, Johannes Fitzgerald De Boer: Method and apparatus for performing optical imaging using frequency-domain interferometry. The General Hospital Corporation, Dorsey & Whitney, June 8, 2010: US07733497 (118 worldwide citation)

An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An inte ...