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Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie: Hiv inhibiting 5-amido substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, WANTE Dirk, October 11, 2007: WO/2007/113254 (47 worldwide citation)

This invention concerns pyrimidine derivatives of formula having HIV (Human Immunodeficiency Virus) replication inhibiting properties, the preparation thereof and pharmaceutical compositions comprising these compounds.


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Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Janssen Paul Adriaan Jan: Hiv inhibiting bicyclic pyrimidine derivatives. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Arts Frank Xavier Jozef Herwig, WANTE Dirk, May 4, 2006: WO/2006/045828 (46 worldwide citation)

HIV replication inhibitors of formula (I) N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a1=a2-a3=a4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH- CH=N-, -N=N-CH=CH-; -b1=b2-b3=b4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, ...


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Guillemont Jerôme Emile Georges, Mordant Céline Isabelle, Schmitt Benoit Antoine: Hiv inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Mordant Céline Isabelle, Schmitt Benoit Antoine, WANTE Dirk, October 11, 2007: WO/2007/113256 (30 worldwide citation)

This invention concerns 5-(hydroxymethylene and aminomethylene)pyrimidine derivatives having HIV (Human Immunodeficiency Virus) replication inhibiting properties, to the preparation thereof and to pharmaceutical compositions comprising these compounds.


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Guillemont Jerôme Emile Georges, Heeres Jan, Lewi Paulus Joannes: Hiv inhibiting 5-heterocyclyl pyrimidines. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Heeres Jan, Lewi Paulus Joannes, WANTE Dirk, April 6, 2006: WO/2006/035067 (11 worldwide citation)

HIV replication inhibitors of formula (I), N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a1=a2-a3=a4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N-, -N=N-CH=CH-; -b1=b2-b3=b4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, ...


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Guillemont Jerôme Emile Georges, Heeres Jan, Lewi Paulus Joannes: Hiv inhibiting 5-substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Heeres Jan, Lewi Paulus Joannes, WANTE Dirk, April 6, 2006: WO/2006/035069 (10 worldwide citation)

HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A is -CH2-CH2- , -CH=CH- , -C≡C- ; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, R2 hydroxy, h ...


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GUILLEMONT JERÔME EMILE GEORGES: Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines. TIBOTEC PHARMACEUTICALS, Wante Dirk, April 6, 2006: WO/2006/035068 (9 worldwide citation)

HIV replication inhibitors of formula (I) N-oxides, a pharmaceutically acceptable addition salts, a quaternary amines or a stereoisomeric forms thereof, wherein -a1=a2-a3=a4 - is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH- CH=N-, -N=N-CH=CH-; -b1=b2-b3=b4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH- ...


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Bonfanti Jean François, Andries Koenraad Jozef Lodewijk, Janssens Frans Eduard, Sommen François Maria, Guillemont Jerôme Emile Georges, Lacrampe Jean Fernand Armand: Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication. Tibotec Pharmaceuticals, Bonfanti Jean François, Andries Koenraad Jozef Lodewijk, Janssens Frans Eduard, Sommen François Maria, Guillemont Jerôme Emile Georges, Lacrampe Jean Fernand Armand, WANTE Dirk, June 30, 2005: WO/2005/058870 (1 worldwide citation)

The present invention concerns amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I) their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is Ar1 or C1-6alk ...


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Bonfanti Jean François, Andries Koenraad Jozef Lodewijk, Janssens Frans Eduard, Sommen François Maria, Guillemont Jerôme Emile Georges, Lacrampe Jean Fernand Armand: Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication. Tibotec Pharmaceuticals, Bonfanti Jean François, Andries Koenraad Jozef Lodewijk, Janssens Frans Eduard, Sommen François Maria, Guillemont Jerôme Emile Georges, Lacrampe Jean Fernand Armand, WANTE Dirk, June 30, 2005: WO/2005/058873 (1 worldwide citation)

The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I) their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C1- ...