1
Gregory P Winter: Recombinant altered antibodies and methods of making altered antibodies. Medical Research Council, Spencer Frank & Schneider, July 6, 1993: US05225539 (1061 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...


2
Hendricus R J M Hoogenboom, Michael Baier, Laurent S A T Jespers, Gregory P Winter: Production of chimeric antibodies - a combinatorial approach. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 15, 1996: US05565332 (754 worldwide citation)

Methods are disclosed which may be used for the production of antibodies, or antibody fragments, which have the same binding specificity as a parent antibody but which have increased human characteristics. Humanized antibodies may be obtained by chain shuffling, perhaps using phage display technolog ...


3
Gregory P Winter, Alexander R Duncan, Dennis R Burton: Antibodies with altered effector functions. Scotgen Biopharmaceuticals Incorporated, Spencer & Frank, April 29, 1997: US05624821 (552 worldwide citation)

An antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by replacing at least one amino acid residue in the constant portion of the antibody with a different residue.


4
Gregory P Winter, Lutz Riechmann, William D Huse, Joseph A Sorge, Richard A Lerner: Method for tapping the immunological repertoire. Scripps Research Institute, Medical Research Council, Stratagene, Albert P Halluin, Viola T Kung, Howrey Simon Arnold & White, September 18, 2001: US06291158 (100 worldwide citation)

The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.


5
Michael J Embleton, Guy Gorochov, Peter T Jones, Gregory P Winter: In situ recombinant PCR within single cells. Medical Research Council, Cushman Darby & Cushman IP Group of Pillsbury Madison & Sutro, November 3, 1998: US05830663 (78 worldwide citation)

Disclosed is a method of treating a heterogeneous population of cells to link together copies of two or more nucleic acid sequences from at least some of the cells, the arrangement being such that copies of the DNA sequences from an individual cell are preferentially linked in the vicinity of the nu ...


6
Richard A Lerner, Joseph A Sorge, Gregory P Winter, Lutz Riechmann: Method for tapping the immunological repertiore. Scripps Research Institute, Medical Research Council, Stratagene, Albert P Halluin, Viola T Kung, Howrey Simon Arnold White, September 18, 2001: US06291161 (53 worldwide citation)

The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.


7
Gregory P Winter, Lutz Riechmann, William D Huse, Joseph A Sorge, Richard A Lerner: Method for producing polymers having a preselected activity. Scripps Research Institute, Medical Research Council, Stratagene, Albert P Halluin, Viola T Kung, Howrey Simon Arnold & White, September 18, 2001: US06291159 (41 worldwide citation)

The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.


8
Stephen J Russell, Robert E Hawkins, Gregory P Winter: Recombinant viruses displaying a nonviral polypeptide on their external surface. Medical Research Council, Kathleen Madden Williams, March 3, 1998: US05723287 (27 worldwide citation)

We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic ...


9
Richard A Lerner, Joseph A Sorge, Gregory P Winter, Lutz Riechmann: Method for tapping the immunological repertoire. Scripps Research Institute, Medical Research Council, Stratagene, Howrey Simon Arnold & White, November 29, 2005: US06969586 (25 worldwide citation)

The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.


10
Herman Waldmann, Michael R Clark, Gregory P Winter, Lutz Riechmann: Antibodies to the antigen campath-1. British Technology Group, Nixon & Vanderhye, December 8, 1998: US05846534 (24 worldwide citation)

An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including frame ...