1
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney: Rapid gelling biocompatible polymer composition. Cohesion Technologies, Dianne E Reed, Laurie A Axord, November 6, 2001: US06312725 (217 worldwide citation)

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, ...


2
Gregory M Cruise, Olexander Hnojewyj: Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers. NeoMend, Ryan Kromholz & Manion, April 16, 2002: US06371975 (147 worldwide citation)

A biocompatible and biodegradable barrier material is applied to a tissue region, e.g., to seal a vascular puncture site. The barrier material comprises a compound, which is chemically cross-linked without use of an enzyme to form a non-liquid mechanical matrix. The compound preferably includes a pr ...


3
Gregory M Cruise, Olexander Hnojewyj: Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue. NeoMend, Ryan Kromholz & Manion S C, October 1, 2002: US06458147 (130 worldwide citation)

A biocompatible and biodegradable hydrogel compound, which is free of a hemostatic agent, is applied to arrest the flow of blood or fluid from body tissue. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(et ...


4
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney, Olof Mikael Trollsas: Rapid-gelling biocompatible polymer composition and associated methods of preparation and use. Cohesion Technologies, Dianne K Reed, Reed & Eberle, September 23, 2003: US06624245 (118 worldwide citation)

A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m≧2 and a biocompatible crosslinking ...


5
George R Greene Jr, Gregory M Cruise, Michael Constant, Brian J Cox: Filamentous embolic device with expansile elements. Microvention, Klein O&apos Neill & Singh, August 5, 2003: US06602261 (107 worldwide citation)

An embolization device includes one or more expansible, hydrophilic embolizing elements non-releasably carried along the length of a filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element i ...


6
Gregory M Cruise, Olexander Hnojewyj: Systems for applying cross-linked mechanical barriers. NeoMend, Ryan Kromholz & Manion S C, February 7, 2006: US06994686 (54 worldwide citation)

A delivery device applies a biocompatible and biodegradable barrier material to a tissue region, e.g., to seal a vascular puncture site. The material comprises two liquid components, which are pre-packaged in individual dispensers. Upon mixing, the liquid components cross-link to create a barrier ma ...


7
George R Greene Jr, Gregory M Cruise, Michael Constant, Brian J Cox, Terrance Tran: Method of manufacturing expansile filamentous embolization devices. Microvention, Klein O Neill & Singh, Howard J Klein, March 21, 2006: US07014645 (52 worldwide citation)

An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium ...


8
Gregory M Cruise, Michael J Constant: Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use. MicroVention, Robert D Buyan, Stout Uxa Buyan & Mullins, April 12, 2005: US06878384 (45 worldwide citation)

Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion( ...


9
Gregory M Cruise: Radiation cross-linked hydrogels. MicroVention, Robert D Buyan, Stout Uxa Buyan & Mullins, March 25, 2003: US06537569 (32 worldwide citation)

Radiation-crosslinked, biodrgradable, synthetic hydrogels and their use in various applications, including certain medical applications wherein the hydrogel(s) are implanted on or in the body of a human or animal patient. Radiation-crosslinked, biodrgradable, synthetic hydrogels of this invention ma ...


10
Olexander Hnojewyj, Charles F Milo, Gregory M Cruise: Biocompatible material composition adaptable to diverse therapeutic indications. NeoMend, Ryan Kromholz & Manion S C, May 31, 2005: US06899889 (27 worldwide citation)

A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.