1
Robert Stern, Gregory I Frost, Anthony Csóka, Tim M Wong: Use of human plasma hyaluronidase in cancer treatment. The Regents of the University of California, Carol L Francis, Paula A Borden, Bozicevic Field&FrancisLLP, December 12, 2006: US07148201 (42 worldwide citation)

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for ...


2
Louis H Bookbinder, Anirban Kundu, Gregory I Frost: Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof. Halozyme, K & L Gates, Stephanie Seidman, August 3, 2010: US07767429 (41 worldwide citation)

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the ...


3
Robert Stern, Gregory I Frost, Jackson Hall, Svetlana Shuster, Gail T Colbern, Bent Formby: BH55 hyaluronidase. The Regents of the University of California, Carol L Bozicevic & Reed Francis, October 27, 1998: US05827721 (36 worldwide citation)

The invention features a purified hyaluronidase BH55 polypeptide isolated from a mammalian species, preferably bovine or human. The invention also features DNA encoding BH55, vectors and transformed host cells containing DNA encoding BH55, methods of making BH55 hyaluronidase polypeptides, and antib ...


4
Robert Stern, Gregory I Frost, Jackson Hall, Svetlana Shuster, Bent Formby, Gail T Colbern: BH55 hyaluronidase. The Regents of the University of California, Sansum Medical Research Foundation, California Pacific Medical Center Research Institute, Karl Bozicevic, Carol L Fish & Richardson P C Francis, May 5, 1998: US05747027 (35 worldwide citation)

The invention features a purified hyaluronidase BH55 polypeptide isolated from a mammalian species, preferably bovine or human. The invention also features DNA encoding BH55, vectors and transformed host cells containing DNA encoding BH55, the methods of making BH55 hyaluronidase polypeptides, and t ...


5
Robert Stern, Gregory I Frost, Anthony Csóka, Tim M Wong: Method of treating tumor-bearing patients with human plasma hyaluronidase. The Regents of the University of California, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, February 27, 2001: US06193963 (28 worldwide citation)

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for ...


6
Robert Stern, Gregory I Frost, Anthony Csoka, Tim M Wong: Human plasma hyaluronidase. The Regents of the University of California, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, September 12, 2006: US07105330 (28 worldwide citation)

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for ...


7
Robert Stern, Anthony Csoka, Gregory I Frost, Tim M Wong: Human urinary hyaluronidase. The Regents of the University of California, Carol L Bozicevic Field & Francis Francis, September 26, 2000: US06123938 (28 worldwide citation)

The present invention is based on the purification and sequencing of isozymes of plasma hyaluronidase (pHAse) found in urine. Specifically, urine contains two hyaluronidases (HAses): 1) a 57 kDa HAse that is apparently the same as the 57 kDa HAse found in plasma; and 2) a 45 kDa HAse, which is found ...


8
Robert Stern, Gregory I Frost, Anthony Csoka, Tim M Wong: Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase. The Regents of the University of California, Carol L Bozicevic & Reed Francis, August 15, 2000: US06103525 (26 worldwide citation)

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for ...


9
Louis H Bookbinder, Anirban Kundu, Gregory I Frost: Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases. Halozyme, K & L Gates, Stephanie Seidman, January 18, 2011: US07871607 (25 worldwide citation)

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the s ...


10
Louis H Bookbinder, Anirban Kundu, Gregory I Frost: Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases. Halozyme, K & L Gates, Stephanie Seidman, November 9, 2010: US07829081 (25 worldwide citation)

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the s ...