1
Gregory D Plowman: Assay for agents active in proliferative disorders. Sugen, Lyon & Lyon, September 8, 1998: US05804396 (79 worldwide citation)

Method for identifying an agent for treatment of a proliferative disorder, comprising the steps of assaying a potential agent for activity in inhibition of signal transduction by a HER2/HER3 or HER2/HER4 or HER3/HER4 heterodimer. Method of screening for an agent that selectively inhibits the kinase ...


2
Joseph P Brown, Charles D Estin, Gregory D Plowman, Timothy M Rose, Karl E Hellstrom, Ingegerd Hellstrom, Anthony F Purchio, Shiu Lok Hu, Sridhar Pennathur: Recombinant viruses encoding the human melanoma-associated antigen. Oncogen, Pennie & Edmonds, November 16, 1993: US05262177 (53 worldwide citation)

Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which can induce an immune response that ...


3
Gregory D Plowman, Jean Michel Culouscou, Mohammed Shoyab, Clay B Siegall, Ingegerd Hellstrom, Karl E Hellstrom: Antibodies to HER4, human receptor tyrosine kinase. Bristol Myers Squibb Company, Brian Poor, Thomas R Savitsky, September 22, 1998: US05811098 (47 worldwide citation)

The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4, are described. Antibodies to HER4 are disclosed. A HER4 ligand capable of inducing cellular differentiation of breast can ...


4
Joseph P Brown, Charles D Estin, Gregory D Plowman, Timothy M Rose, Karl E Hellstrom, Ingegerd Hellstrom, Anthony Purchio, Shiu Lok Hu, Sridhar Pennathur: Vaccines against melanoma. Oncogen, August 25, 1992: US05141742 (24 worldwide citation)

Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which can induce an immune response that ...


5
Mohammed Shoyab, Vicki L McDonald, James G Bradley, Gregory D Plowman: Amphiregulin: a bifunctional growth modulating glycoprotein. Oncogen, Pennie & Edmonds, May 19, 1992: US05115096 (21 worldwide citation)

A novel cell growth regulatory factor, named Amphiregulin, is described. This extremely hydrophilic glycoprotein, having a median molecular weight of 22,500 daltons, demonstrates unusual biological activity. Amphiregulin is a bifunctional cell growth regulatory factor which exhibits potent inhibitor ...


6
Mohammed Shoyab, Vicki Lynn McDonald, James Garrett Bradley, Gregory D Plowman: Fanphiregulins: a family of heparin-binding epithelial cell growth factors. Bristol Myers Squibb Company, Pennie & Edmonds, November 3, 1998: US05830995 (14 worldwide citation)

The present invention is directed to a family of heparin-binding epithelial cell growth factors termed amphiregulins (AR). In particular, it relates to the isolation of AR genes from different animal species, expression of the genes, identification of various forms of biologically active AR products ...


7
Mohammed Shoyab, Gregory D Plowman: Epithelins: novel cysteine-rich growth modulating proteins. Bristol Myers Squibb Company, S Leslie Misrock, Pennie & Edmonds, May 16, 1995: US05416192 (12 worldwide citation)

A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and P ...


8
Wei Ching Liang, Gregory D Plowman, Yan Wu, Weilan Ye: Antibodies. Genentech, Morrison & Foerster, July 5, 2011: US07973138 (9 worldwide citation)

The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising nove ...


9
Gregory D Plowman, Susan Onrust, David Markby, Sara Courtneidge: Diagnosis and treatment of SAD related disorders. Sugen, Foley & Lardner, May 14, 2002: US06388063 (7 worldwide citation)

The present invention relates to SAD polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, ...


10
Gregory D Plowman, Douglas Clary: Diagnosis and treatment of alk-7 related disorders. Sugen, Beth A Burrous, Foley & Lardner, November 16, 2004: US06818440 (4 worldwide citation)

The present invention relates to ALK-7 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis ...