1
Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


2
Graham Samuel L, Desolms S Jane: Inhibitors of farnesyl protein transferase.. Merck & Co, April 7, 1993: EP0535730-A2 (53 worldwide citation)

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-prote ...


3
Bell Ian M, Graham Samuel L, Williams Theresa M, Stump Craig A: Benodiazepine spirohydantoin cgrp receptor antagonists. Merck & Co, Bell Ian M, Graham Samuel L, Williams Theresa M, Stump Craig A, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, October 14, 2004: WO/2004/087649 (25 worldwide citation)

The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprisin ...


4
Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Yang Wenjin, Lu Wanli, Fahr Bruce: Spiropiperidine beta-secretase inhibitors for the treatment of alzheimers disease. Merck & Co, Sunesis Pharmaceuticals, Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Yang Wenjin, Lu Wanli, Fahr Bruce, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, January 25, 2007: WO/2007/011810 (19 worldwide citation)

The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also d ...


5
Hills Ivory D, Coburn Craig A, Graham Samuel L, Moore Keith P, Nantermet Philippe G, Rajapakse Hemaka A, Stachel Shawn J, Zhu Hong: 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimers disease. Merck & Co, Hills Ivory D, Coburn Craig A, Graham Samuel L, Moore Keith P, Nantermet Philippe G, Rajapakse Hemaka A, Stachel Shawn J, Zhu Hong, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, September 3, 2009: WO/2009/108550 (18 worldwide citation)

The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceuti ...


6
Graham Samuel L, Hungate Randall W, Huff Joel R, Lyle Terry A, Young Steven D, Britcher Susan F, Scholz Thomas H, Payne Linda S, Dorsey Bruce D: Hiv protease inhibitors having polyether substituents.. Merck & Co, May 27, 1992: EP0487270-A2 (14 worldwide citation)

Polyether derivatives of the form, A-G-B-B-J wherein G is a dipeptide isostere substituted with a polyether, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of DIV protease, the prevention or treatment of infection by HIV an ...


7
Graham Samuel L, Desolms S Jane, Garsky Victor M: Inhibitors of farnesyl protein transferase.. Merck & Co, April 7, 1993: EP0535731-A2 (14 worldwide citation)

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-prote ...


8
Graham Samuel L, Ghosh Arun K, Huff Joel R, Scholz Thomas H: Hiv protease inhibitors with n-terminal polyether substituents.. Merck & Co, February 24, 1993: EP0528661-A2 (13 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is a polyether or ether substituent, G is a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and t ...


9
Shepard Kenneth L, Graham Samuel L, Czaja Robert F, Melillo David G, Hoffman Jacob M Jr: (b) Thiophene derivatives, their preparation and pharmaceutical composition for the treatment of elevated intraocular pressure.. Merck & Co, December 27, 1984: EP0129478-A2 (10 worldwide citation)

Novel 2-sulfamoylbenzo [b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.


10
Graham Samuel L, Scholz Thomas H: Alkanesulfonamides as antiglaucoma agents.. Merck & Co, January 13, 1988: EP0252640-A1 (8 worldwide citation)

Alkane sulfonamides with an electron withdrawing function beta to the sulfonamide group are topically effective carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.