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Saleh Ahmed, Oscar Barba, Jason Bloxham, Graham Dawson, William Gattrell, John Kitchin, Neil Anthony Pegg, Imaad Saba, Shazia Sadiq, Colin Peter Sambrook Smith, Don Smyth, Amo G Steinig, Robin Wilkes, Bijoy Panicker, Paula Tavares, Matthew Cox, An Hu Li, Hanqing Dong, Lifu Ma, Kenneth, Qinghua, Kathryn Stolz: Substituted pyrrolo[2.3-B]pyridines. OSI Pharmaceuticals, December 16, 2008: US07465726 (4 worldwide citation)

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animal ...


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Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano: (2-carboxamido)(3-amino)thiophene compounds. Osi Pharmaceuticals, September 23, 2004: US20040186124-A1

Compounds represented by Formula (I): 1 or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is 2 R2 is 3 and R3 is C0-4alkyl, are useful in the treatment of cancer.


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David M Vicar, Graham Dawson, Mark S Barratt, John B Cox: Cryostat Having Separate Cooling Circuits for Cooling the Chamber and a Sample Holder. Thermo Shandon, Stites & Harbison Pllc, February 21, 2008: US20080041069-A1

According to an aspect of the present invention, a cryostat includes two separate cooling means, one for reducing the temperature in a cooling chamber (2) and the other arranged to cool a freezing plate (8). In one embodiment, there may be a single cooling circuit, with e.g. a single reservoir of re ...


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Saleh Ahmed, Celine Combet, Scott Cuthill, Graham Dawson, William Gattrell, Mario Lobell, Neil Pegg, Imaad Saba, Simon Swain, Claire Thomas, Graham Wynne: Mercaptoamides as histone deacetylase inhibitors. Osi Pharmaceuticals, March 2, 2006: US20060047123-A1

Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.


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Saleh Ahmed, Oscar Barba, Jason Bloxham, Graham Dawson, Wiliam Gattrell, John Kitchin, Neil Anthony Pegg, Imaad Saba, Shazia Sadiq, Colin Peter Sambrook Smith, Don Smyth, Amo G Steing, Robin Wilkes, Bijoy Panicker, Paula Tavares, Matthew Cox, An Hu Li, Hanqing Dong, Lifu Ma, Kenneth, Qinghua, Kathryn Stolz: Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds. Osi Pharmaceuticals, September 21, 2006: US20060211678-A1

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animal ...


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Oscar Barba, Graham Dawson, William Gattrell, Martin James Procter, Chrystelle Marie Rasamison, Colin Peter Sambrook Smith, Philippe Wong Kai In: Amide and urea derivatives for the treatment of metabolic diseases. Prosidion, Osi Pharmaceuticals, April 15, 2010: US20100093733-A1

Compounds of formula (I): or pharmaceutically acceptable salts and esters thereof, are useful for the treatment of obesity, type II diabetes and the metabolic syndrome.


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Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O Geisser, Vincent A Corden, Stephen M Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P Ridgill, Chrostopher J Yarnold, Susan Boyce, Albertus A Ellenbroek: Novel Sulfonaminoquinoline Hepcidin Antagonists. Vifor, August 23, 2012: US20120214803-A1

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection wit ...


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Wilm Buhr, Susanna Burckhardt, Franz Dürrenberger, Felix Funk, Peter O Geisser, Vincent A Corden, Stephen M Courtney, Graham Dawson, Tara Davenport, Mark Slack, Mark P Ridgill, Christopher J Yarnold, Susan Boyce, Albertus A Ellenbroek: Sulfonaminoquinoline hepcidin antagonists. Vifor, Rankin Hill & Clark, August 11, 2015: US09102688

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection wit ...