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Abel Ulrich, Deppe Holger, Feurer Achim, Grädler Ulrich, Goutopoulos Andreas, Schwarz Matthias: Novel 4-arylamino pyridone derivatives as mek inhibitors for the treatment of hyperproliferative disorders. Laboratoires Serono, Abel Ulrich, Deppe Holger, Feurer Achim, Grädler Ulrich, Goutopoulos Andreas, Schwarz Matthias, ZIMMER Franz Josef, June 1, 2006: WO/2006/056427 (15 worldwide citation)

The invention provides novel, substituted 4-arylamino pyridone compounds (formula (I)), pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R 1, R2, R9, R 10, R 11, R 12, R 13, R 14 and L are as defined in the specification. Such compounds are MEK inhibitors and use ...


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Abel Ulrich, Deppe Holger, Feurer Achim, Grädler Ulrich, Otte Kerstin, Sekul Renate, Thiemann Meinolf, Goutopoulos Andreas, Schwarz Matthias, Jiang Xuliang: 3-arylamino pyridine derivatives. Applied Research Systems Ars Holding, Abel Ulrich, Deppe Holger, Feurer Achim, Grädler Ulrich, Otte Kerstin, Sekul Renate, Thiemann Meinolf, Goutopoulos Andreas, Schwarz Matthias, Jiang Xuliang, GOLDBACH Klara, May 4, 2006: WO/2006/045514 (11 worldwide citation)

The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of ...


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Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry: Novel arylamino n-heteraryls as mek inhibitors. Laboratoires Serono, Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry, DAVIS Steven G, November 1, 2007: WO/2007/123939 (10 worldwide citation)

The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed. is the treatment of a hyperproliferative disease in mammals, and phar ...


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HUCK Bayard R, JONES Reinaldo, XIAO Yufang, NEAGU Constantin, BANKSTON Donald, GOUTOPOULOS Andreas: QUINAZOLINE CARBOXAMIDE AZÉTIDINES, QUINAZOLINE CARBOXAMIDE AZETIDINES. Merck Patent, HUCK Bayard R, JONES Reinaldo, XIAO Yufang, NEAGU Constantin, BANKSTON Donald, GOUTOPOULOS Andreas, May 31, 2012: WO/2012/069146 (6 worldwide citation)

The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.


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Magar Sharad, Goutopoulos Andreas, Liao Yihua, Schwarz Matthias, Russell Thomas J: Piperazine derivatives and methods of use. Applied Research Systems Ars Holding, Magar Sharad, Goutopoulos Andreas, Liao Yihua, Schwarz Matthias, Russell Thomas J, SERONO INTERNATIONAL INTELLECTUAL PROPERTY, April 15, 2004: WO/2004/031182 (5 worldwide citation)

The invention provides 2-carboxamide piperazine compounds of formula I, R3 . I N\ ' N ˜` R2 I(0)z- o R4 I wherein R', R2, R3 and R4 are as defined in the claims and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the i ...


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Goutopoulos Andreas, Askew Benny C Jr, Chen Xiaoling, Karra Srinivasa, Yu Henry: Novel heteroaryl-substituted arylaminopyridine derivatives as mek inhibitors. Laboratoires Serono, Goutopoulos Andreas, Askew Benny C Jr, Chen Xiaoling, Karra Srinivasa, Yu Henry, DAVIS Steven G, November 1, 2007: WO/2007/123936 (4 worldwide citation)

The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperp ...


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ABEL ULRICH, DEPPE HOLGER, FEURER ACHIM, GRAEDLER ULRICH, OTTE KERSTIN, SEKUL RENATE, THIEMANN MEINOLF, GOUTOPOULOS ANDREAS, SCHWARZ MATTHIAS, JIANG XULIANG: DERIVES DE 3-ARYLAMINO PYRIDINE, 3-ARYLAMINO PYRIDINE DERIVATIVES. APPLIED RESEARCH SYSTEMS ARS HOLDING, MERCK SERONO, KIRBY EADES GALE BAKER, February 11, 2014: CA2582247 (4 worldwide citation)

The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of ...


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DONNELLY Marianne, QIU Hui, YU Henry, LIU BUJALSKI Lesley, GOUTOPOULOS Andreas: [fr] PYRANO[3,2-D][1,3]THIAZOLE FORMANT DES INHIBITEURS DE LA GLYCOSIDASE, [en] PYRANO [3, 2 - D] [1, 3] THIAZOLE AS GLYCOSIDASE INHIBITORS. DONNELLY Marianne, QIU Hui, YU Henry, LIU BUJALSKI Lesley, GOUTOPOULOS Andreas, Merck Patent, BROWN Thomas W, February 28, 2013: WO/2013/028715 (4 worldwide citation)

[en] Novel compounds of formula (I), wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.