1
Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


2
Thompson Wayne J, Vacca Joseph P, Huff Joel R, Lyle Terry A, Young Steven D, Hungate Randall W, Britcher Susan F, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, June 26, 1991: EP0434365-A2 (69 worldwide citation)

Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the preven ...


3
Thompson Wayne J, Ghosh Arun K, Lee Hee Yoon, Huff Joel R: Hiv protease inhibitors.. Merck & Co, April 28, 1993: EP0539192-A1 (42 worldwide citation)

Oligopeptide analogs are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination w ...


4
Vacca Joseph P, Ghosh Arun K, Chen Lin Tsen Jenny, Hungate Randall W: 2-pyrrolidinone derivatives as hiv protease inhibitors.. Merck & Co, July 14, 1993: EP0550924-A1 (18 worldwide citation)

Compounds of the form, A-B-G-J wherein A is an amine protecting group and the like, B an amino acid or analog thereof, wherein G is and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatm ...


5
Graham Samuel L, Ghosh Arun K, Huff Joel R, Scholz Thomas H: Hiv protease inhibitors with n-terminal polyether substituents.. Merck & Co, February 24, 1993: EP0528661-A2 (13 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is a polyether or ether substituent, G is a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and t ...


6
Ghosh Arun K: Quinazoline inhibitors of bace 1 and methods of using. PURDUE RESEARCH FOUNDATION, Addison Bradford G, May 27, 2010: WO/2010/059953 (11 worldwide citation)

Dihydroquinazoline compounds, compositions containing them, the use of the compounds and compositions for the treatment of Alzheimer' s disease are described.


7
Ghosh Arun K, Huff Joel R, Thompson Wayne J, Lyle Terry A, Hungate Randall W, Mckee Sean P, Lee Hee Yoon: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, March 31, 1993: EP0534511-A1 (10 worldwide citation)

Compounds of the form, A-G-J wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, ...


8
Ghosh Arun K, Leshchenko Sofiya, Noetzel Marcus W: Method of preparing (3r, 3as, 6ar) -3- hydroxyhexahydrofuro [2, 3-b] furan and related compounds. The Board Of Trustees Of The University Of Illinois, NAPOLI James J, April 22, 2004: WO/2004/033462 (7 worldwide citation)

A method of synthesizing (3R, 3aS, 6aR) -3- hydroxyhexahydrofuro [2, 3-b] furan (I), and related compounds, in high yield and high enantiomeric selectivity is disclosed. Also disclosed is a method of manufacturing (5S) -5-(benzyloxymethyl) -5H-furan-2-one.


9
Ghosh Arun K, Mitsuya Hiroaki, Koh Yasuhiro: Method and compositions for treating hiv infections. Purdue Research Foundation, Ghosh Arun K, Mitsuya Hiroaki, Koh Yasuhiro, ADDISON Bradford G, November 6, 2008: WO/2008/133734 (6 worldwide citation)

Described herein are compounds and compositions that are useful in the treatment of HIV, AIDS, and AIDS-related diseases. In addition, compounds are described herein that are capable of inhibiting the dimerization of HIV proteases.


10
GHOSH Arun K: [fr] INHIBITEURS DE PROT√ČASE DE VIH-1 NON PEPTIDIQUES, [en] NONPEPTIDE HIV-1 PROTEASE INHIBITORS. GHOSH Arun K, PURDUE RESEARCH FOUNDATION, ADDISON Bradford G, January 7, 2010: WO/2010/002994 (5 worldwide citation)

[en] Novel compounds and compositions for treating patients in need of relief from HIV, AIDS, and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described.