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Gerrard M Carlson, Veerichetty A Kadhiresan, Julio C Spinelli: Heart rate variability as an indicator of exercise capacity. Cardiac Pacemakers, Nikolai Merserau & Dietz P A, February 15, 2000: US06026320 (337 worldwide citation)

Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient' ...


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Jan P Heemels, Gerrard M Carlson, Julio C Spinelli: Data logging system for implantable cardiac device. Cardiac Pacemakers, Haugen and Nikolai P A, February 18, 1997: US05603331 (183 worldwide citation)

An implantable cardiac rhythm management device (pacemaker or defibrillator) having circuitry for determining the interval between two successive natural ventricular depolarization signals, includes the capability of computing and storing histogram arrays of heart rate variability data over a prolon ...


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Gerrard M Carlson, Bruce R Jones, Julio C Spinelli: Acceleration sensed safe upper rate envelope for calculating the hemodynamic upper rate limit for a rate adaptive cardiac rhythm management device. Cardiac Pacemakers, Haugen and Nikolai P A, August 11, 1998: US05792195 (146 worldwide citation)

An implantable cardiac rhythm management device includes an accelerometer along with apparatus for processing the analog signal output from the accelerometer for deriving therefrom the time of occurrence of a selected heart sound in relation to a previously occurring ventricular depolarization event ...


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Qingsheng Zhu, Julio C Spinelli, Gerrard M Carlson: Accelerometer-based heart sound detection for autocapture. Cardiac Pacemakers, C G Mersereau, Nikolai & Mersereau P A, November 18, 2003: US06650940 (122 worldwide citation)

An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S


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Krzysztof Z Siejko, Laura Green, Gerrard M Carlson: Third heart sound activity index for heart failure monitoring. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, October 3, 2006: US07115096 (113 worldwide citation)

A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart beats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An ...


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Avram Scheiner, William Hsu, David M Flynn, Qingsheng Zhu, John E Heil, Ronald W Heil Jr, Curtis C Lindstrom, Robert S Booker III, Yayun Lin, Peter T Kelley, Jay A Warren, Gerrard M Carlson, Carol Werlein, Aaron W Janke, Mary Lee Cole, Jeffrey T Bartig, Gary W Goebel, Douglas A Heitkamp, Randall M Peterfeso: Single pass lead system. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, April 3, 2001: US06212434 (108 worldwide citation)

A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. Th ...


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Gerrard M Carlson: Cardiac pre-ejection period detection. Cardiac Pacemakers, Haugen And Nikolai P A, October 7, 1997: US05674256 (86 worldwide citation)

A method of and apparatus for controlling a rate adaptive pacer is disclosed which operates based on the pre-ejection period (PEP), the method including the step of detecting the pre-ejection period utilizing only the pacer ECG signal and an accelerometer transducer signal.


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Qingsheng Zhu, Julio C Spinelli, Bruce H KenKnight, Gerrard M Carlson: Cardiac rhythm management device with triggered diagnostic mode. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, June 13, 2006: US07062314 (74 worldwide citation)

A device and method in which spectral analysis of heart rate variability is performed in order to assess autonomic balance. When a threshold level is reached, a diagnostic mode is triggered in which the device performs computationally intensive data analysis to assess the probability of a pathologic ...