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Gerhard Bienhaus, Hans Lange: Device for treating nucleic acids from a sample. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, May 5, 1998: US05746978 (143 worldwide citation)

Device for the treatment of nucleic acids from the sample, comprising a first reaction chamber for separating the nucleic acids from other sample components, and a second reaction chamber for the amplification of the nucleic acids, connected to said first reaction chamber via a controllable transpor ...


2
Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch: System for releasing and isolating nucleic acids. Roche Diagnostics, Arent Fox Kintner Plotkin Kahn, September 12, 2000: US06117398 (112 worldwide citation)

An instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.


3
Heinz Macho, Gerhard Bienhaus: System for the temperature adjustment treatment of liquid samples. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, July 6, 1999: US05919622 (80 worldwide citation)

A system for the temperature adjustment treatment of liquids, especially during the isolation and amplification of nucleic acids with a reusable thermostat element and a disposable heating element has the advantage of a particularly simple means of conducting temperature adjustment treatments. This ...


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Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch: System for releasing and isolating nucleic acids. Roche Diagnostics, Arent Fox, July 19, 2005: US06919175 (70 worldwide citation)

A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magne ...


5
Gerhard Bienhaus, Hans Lange: System for opening closures of vessels and for the contamination-free operation of reaction sequences. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, December 8, 1998: US05846489 (55 worldwide citation)

System for the automatic operation of reactions using several vessels which can be closed by individual closures using a device for automatically opening the closures.


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Gerhard Bienhaus, Burkhard Stolz, Ulrich Schubert: Method of magnetically separating liquid components. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, November 17, 1998: US05837144 (34 worldwide citation)

Method of separating a component of a liquid from other components by immobilizing the component to suspended magnetic particles in a vessel, immersing a magnetic device into the vessel while the device is separated from the liquid by means of a protective sleeve made of a non-magnetic material. The ...


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Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter: System for providing biological materials. Roche Diagnostics, Jill L Woodburn, Richard T Knauer, December 30, 2003: US06669910 (15 worldwide citation)

System and process for isolating purified biological materials with a collecting unit which has collecting vessels that are accessible from above with a matrix unit in which matrix vessels are arranged in a holder as well as a closure unit which can be placed on the collecting unit to close the coll ...


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Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho: Lid for closing vessels. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, September 28, 1999: US05957822 (11 worldwide citation)

A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed on an outer ...


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Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho: Vessel for reducing contamination in the treatment of liquids. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, January 5, 1999: US05855852 (10 worldwide citation)

A vessel for reducing contamination of liquids is formed of a vessel body with an inlet opening and an outlet opening therein. A closing device is attached to the vessel body adjacent the outlet opening. The closing device closes the outlet opening, and includes a normally closed one-way valve which ...


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