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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. Nimbus Iris, Choate Hall & Stewart, Andrea C Robidoux, Thomas H McLean, April 22, 2014: US08703941 (8 worldwide citation)

The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.


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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. NIMBUS IRIS, Dechert, Andrea L C Reid, May 17, 2016: US09340554 (1 worldwide citation)

The present invention provides 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine compounds and pharmaceutical compositions thereof as inhibitors of IRAK.


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Geraldine C Harriman, Craig E Masse, James Harwood, Sathesh Bhat, Jeremy Robert Greenwood: ACC inhibitors and uses thereof. Nimbus Apollo, Choate Hall & Stewart, Andrea L C Reid, Thomas H McLean, March 3, 2015: US08969557 (1 worldwide citation)

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.


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Donna Romero, Craig E Masse, Shaughnessy Robinson, Jeremy Robert Greenwood, Geraldine C Harriman: IRAK inhibitors and uses thereof. Nimbus Iris, Andrea L C Reid, Dechert, December 13, 2016: US09518065

The present invention provides compounds of the general formula I: or a pharmaceutically acceptable salt thereof, wherein each variable is as defined and described herein, as inhibitors of one or more interleukin-1 receptor-associated kinases (“IRAK”).


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Geraldine C Harriman, Craig E Masse, James Harwood, Sathesh Bhat, Jeremy Robert Greenwood: ACC inhibitors and uses thereof. Gilead Apollo, Sheppard Mullins Richter & Hampton, September 27, 2016: US09453026

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.


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Craig E Masse, Jeremy Robert Greenwood, Donna L Romero, Geraldine C Harriman, Ronald T Wester, Mee Shelley, Joshua Jahmil Kennedy Smith, Markus Dahlgren: TYK2 inhibitors and uses thereof. NIMBUS LAKSHMI, Dechert, Andrea L C Reid, May 17, 2016: US09340540

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.


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Craig E Masse, Jeremy Robert Greenwood, Donna L Romero, Geraldine C Harriman, Ronald T Wester, Mee Shelley, Joshua Jahmil Kennedy Smith, Markus Dahlgren: TYK2 inhibitors and uses thereof. Nimbus Lakshmi, Andrea L C Reid, Dechert, April 25, 2017: US09630970

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.