1
Henry K Tom, Gerald L Rowley: Concentrating zone method in heterogeneous immunoassays. Syva Company, Bertram I Rowland, December 28, 1982: US04366241 (765 worldwide citation)

Method and apparatus are provided for performing immunoassays employing a device comprising a relatively small test zone referred to as an immunosorbing zone, and a relatively large liquid absorbing zone in liquid receiving relationship with said immunosorbing zone. The immunosorbing zone includes a ...


2
Robert F Zuk, Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Double antibody for enhanced sensitivity in immunoassay. Syva Company, Bertram I Rowland, July 28, 1981: US04281061 (173 worldwide citation)

Method and compositions are provided for performing homogeneous immunoassays. The method involves having a signal producing system, which provides a detectable signal, which system includes a macromolecular member. The determination of the analyte, which is a member of a specific binding pair consis ...


3
Naomi Kameda, Gerald L Rowley: Cleavable labels for use in binding assays. Sclavo, Ciotti & Murashige Irell & Manella, October 25, 1988: US04780421 (56 worldwide citation)

An improvement in an assay method which relies on the detection of a labeled, solubilized specific binding complex is achieved by linking the label to a component of the complex through a bond cleavable under conditions compatible with the assay and with the complex in solution.


4
Gerald L Rowley, Danton Leung, Prithiphal Singh: Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby. Syva Company, Bertram I Rowland, September 2, 1980: US04220722 (31 worldwide citation)

Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically introduced, to a polyamino compound, particularly a polypeptide (including proteins). The method employs a halo ...


5
Allan D Pronovost, Gerald L Rowley: Assays employing dyed microorganism labels. Quidel Corporation, Townsend and Townsend Khourie and Crew, June 13, 1995: US05424193 (30 worldwide citation)

The present invention relates generally to test articles and assays for the detection of analytes in biological fluid samples. More particularly, the present invention relates to test articles an assays which employ dyed microorganisms as visual labels to detect suspected analytes.


6
Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Charge effects in enzyme immunoassays. Syva Company, Bertram I Rowland, September 1, 1981: US04287300 (24 worldwide citation)

A method for determining a member of a specific binding pair-ligand and receptor (antiligand). Reagents employed include a first modified member which provides an electrical field due to the presence of a plurality of ionic charges and a second modified member labeled with a component of a signal pr ...


7
Naomi Kameda, Gerald L Rowley: Labeling design for a binding assay reagent. Sclavo, Irell & Manella, September 25, 1990: US04959306 (19 worldwide citation)

Methods and materials for preparing specific binding reagents with a multiplicity of relatively noninterfering label moieties are described. By spacing the labels at the surface of a specific reagent with bulking agent, increased sensitivity can be achieved without interference between individual la ...


8
Gerald L Rowley, Larry R Hillis: Method to derivatize dextran. Sclavo, Irell & Manella, December 4, 1990: US04975532 (13 worldwide citation)

A method to convert the hydroxyl groups of solubilized dextran to the tresylate forms which can be displaced by a nucleophile is disclosed. The method of the invention requires the reaction of dextran with the tresylating reagent in the presence of dry DMSO. The resulting tresylate can be converted ...


9
Ronald Robert C, Phuc H Nguyen, Gerald L Rowley: Fluorescein-conjugated proteins with enhanced fluorescence. Irell & Manella, January 16, 1990: US04894348 (10 worldwide citation)

A method for conducting assays for an analyte, usually in a biological sample, utilizes reagents which contain biological ligands linked to fluorescein or a derivative of fluorescein through a linkage to the fluorescein nucleus selected from acetamido and thioacetamido. In these reagents, the fluore ...


10
Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Charge effects in enzyme immunoassays. Syva Company, Bertram I Rowland, Theodore J Leitereg, February 26, 1985: US04501692 (10 worldwide citation)

A method for determining a member of a specific binding pair-ligand and receptor (antiligand). Reagents employed include a first modified member which provides an electrical field due to the presence of a plurality of ionic charges and a second modified member labeled with a component of a signal pr ...