1
Amit Kumar, George M Whitesides: Formation of microstamped patterns on surfaces and derivative articles. President And Fellows Of Harvard College, Wolf Greenfield & Sacks, April 30, 1996: US05512131 (707 worldwide citation)

A method of patterning a material surface is provided in which an elastomeric stamp having a stamping surface is coated with a self-assembled monolayer forming species having a functional group selected to bind to a particular material, and the stamping surface is placed against a surface of materia ...


2
Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J Jackman, Xiao Mei Zhao, Stephen P Smith, Mara G Prentiss, George M Whitesides, Christian Marzolin: Method of forming articles including waveguides via capillary micromolding and microtransfer molding. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, March 12, 2002: US06355198 (305 worldwide citation)

Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active ...


3
Cynthia C Bamdad, George B Sigal, Jack L Strominger, George M Whitesides: Molecular recognition at surfaces derivatized with self-assembled monolayers. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, April 15, 1997: US05620850 (251 worldwide citation)

An article suitable for use as a biosensor includes a species of a formula X--R--Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the ch ...


4
Rahul Singhvi, Amit Kumar, George M Whitesides, Donald E Ingber, Gabriel P Lopez, Daniel I C Wang, Gregory N Stephanopoulos: Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor. President and Fellows of Harvard College, Massachusetts Institute of Technology, Children s Medical Center Corporation, Wolf Greenfield & Sacks P C, July 7, 1998: US05776748 (237 worldwide citation)

The disclosed invention is a device for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere cells which are isolated by cytophobic regions to which cells do not adhere and further is contiguous wit ...


5
George M Whitesides, Younan Xia, James L Wilbur, Rebecca J Jackman, Enoch Kim, Mara G Prentiss, Milan Mrksich, Amit Kumar, Christopher B Gorman, Hans Biebuyck, Karl K Berggren: Microcontact printing on surfaces and derivative articles. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, January 30, 2001: US06180239 (225 worldwide citation)

Improved method of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, ...


6
George M Whitesides, Amit Kumar: Kit For Microcontact Printing. President & Fellows of Harvard College, Wolf Greenfield & Sacks P C, August 17, 2004: US06776094 (195 worldwide citation)

Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method ...


7
George M Whitesides, Younan Xia, James L Wilbur, Rebecca J Jackman, Enoch Kim, Mara G Prentiss, Milan Mrksich, Amit Kumar, Christopher B Gorman, Hans Biebuyck, Karl K Berggren: Methods of etching articles via microcontact printing. President and fellows of Harvard College, Wolf Greenfield & Sacks P C, May 4, 1999: US05900160 (187 worldwide citation)

Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method ...


8
Paul G Clem, Noo Li Jeon, Milan Mrksich, Ralph G Nuzzo, David A Payne, George M Whitesides, Younan Xia: Self-assembled monolayer directed patterning of surfaces. President and Fellows of Harvard College, Board of Trustees of the University of Illinois, Wolf Greenfield & Sacks P C, February 11, 2003: US06518168 (170 worldwide citation)

A technique for creating patterns of material deposited on a surface involves forming a self-assembled monolayer in a pattern on the surface and depositing, via chemical vapor deposition or via sol-gel processing, a material on the surface in a pattern complementary to the self-assembled monolayer p ...


9
John A Rogers, Rebecca J Jackman, George M Whitesides: Fabrication of small-scale cylindrical articles. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, September 14, 1999: US05951881 (149 worldwide citation)

Techniques for fabrication of small-scale metallic structures such as microinductors, microtransformers and stents are described. A chemically active agent such as a catalyst is applied from an applicator in a pattern to an exterior surface of an article, metal is deposited according to the pattern ...


10
Janelle R Anderson, Oksana Cherniavskaya, Daniel T Chiu, Rebecca J Jackman, Cooper McDonald, George M Whitesides: Microfluidic systems including three-dimensionally arrayed channel networks. President & Fellows of Harvard College, Wolf Greenfield & Sacks P C, November 11, 2003: US06645432 (131 worldwide citation)

The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved micro ...