1
Woonza M Rhee, Richard A Berg, George H Chu, Frank A DeLustro, Dan M Jolivette, Kimberly A McCullough: Injectable or implantable biomaterials for filling or blocking lumens and voids of the body. Collagen Corporation, Morrison & Foerster, May 19, 1998: US05752974 (481 worldwide citation)

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistul ...


2
Karl A Piez, Bruce B Pharriss, George H Chu, Thomas L Smestad, Diana Hendricks: Xenogeneic collagen/mineral preparations in bone repair. Collagen Corporation, Ciotti & Murashige Irell & Manella, January 3, 1989: US04795467 (187 worldwide citation)

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new ...


3
Hoc M Nguyen, George H Chu: Mechanically sheared collagen implant material and method. Collagen Corporation, Ciotti & Murashige, February 10, 1987: US04642117 (167 worldwide citation)

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The ...


4
George H Chu, Jeff E Yeung, Jacqueline Anne Schroeder, Vivek N Shenoy, Melissa K C Brown, James J Cassidy, John Rice: Devices for tissue repair and methods for preparation and use thereof. Neucoll, Morrison & Foerster, July 4, 2000: US06083522 (158 worldwide citation)

Disclosed herein are uniformly shaped swellable devices comprising polymeric materials, as well as apparatuses and processes for their manufacture. In one embodiment, the present invention relates to load bearing implant devices for use in tissue repair. The implants consist of a resorbable, swellab ...


5
Jeffrey E Yeung, George H Chu, Frank A DeLustro, Woonza M Rhee: Anti-adhesion films and compositions for medical use. Collagen Corporation, Laurie A Axford, Shirley L Church, Wilhelmus J Wytenburg, December 3, 1996: US05580923 (156 worldwide citation)

Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient vi ...


6
Donald G Wallace, George H Chu, Jacqueline Anne Schroeder: Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use. Cohesion Technologies, Dianne E Reed, Reed & Associates, December 17, 2002: US06495127 (156 worldwide citation)

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that ...


7
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Methods for tissue repair using adhesive materials. Cohesion Technologies, Dianne E Reed, Mark L Warzel, Reed Intellectual Property Law Group, December 21, 2004: US06833408 (154 worldwide citation)

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction betwe ...


8
Woonza M Rhee, Prema R Rao, George H Chu, Frank A DeLustro, Carol F H Harner, Naomi Sakai, Jacqueline A Schroeder: Collagen-based bioadhesive compositions. Collagen Corporation, Kathi Rafayko, March 25, 1997: US05614587 (153 worldwide citation)

Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprise ...


9
George H Chu, Yasushi Ogawa, John M McPherson, George Ksander, Bruce Pratt, Diana Hendricks, Hugh McMullin: Collagen wound healing matrices and process for their production. Collagen Corporation, Irell & Manella, June 18, 1991: US05024841 (124 worldwide citation)

Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 t ...


10
Woonza M Rhee, Prema R Rao, George H Chu, Frank A DeLustro: Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications. Collagen Corporation, Kathi Rafayko, Shirley L Church, October 15, 1996: US05565519 (102 worldwide citation)

Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantiall ...