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Baetge E Edward, Hammang Joseph P, Gentile Frank T, Lindner Mark D, Winn Shelley R, Emerich Dwaine F: Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules. Cytotherapeutics, Baetge E Edward, Hammang Joseph P, Gentile Frank T, Lindner Mark D, Winn Shelley R, Emerich Dwaine F, sHALEY James F Jr, February 23, 1995: WO/1995/005452 (3 worldwide citation)

This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within ...


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Baetge E Edward, Hammang Joseph P, Gentile Frank T, Lindner Mark D, Winn Shelley R, Emerich Dwaine F: Encapsulated cell system for implantation into the human cns. Cytotherapeutics, February 13, 2002: EP1179350-A2 (2 worldwide citation)

An encapsulated cell system for implantation in the human CNS comprises one or more biocompatible capsules, each capsule containing one or more cells, said cells producing a growth or trophic factor, the encapsulated cell system producing 1-1500 ng/day of the growth or trophic factor, particularly N ...


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Dionne Keith E, Emerich Dwaine F, Hoffman Diane, Scharp David W, Lacy Paul E, Aebischer Patrick, Sanberg Paul R, Christenson Lisa, Hegre Orion D, Vasconcellos Alfred V, Lysaght Michael J, Gentile Frank T: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products.. Univ Brown Res Found, March 9, 1994: EP0585368-A1 (1 worldwide citation)

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, p ...


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Gentile Frank T, Tresco Patrick A, Hazlett Tyrone, Flanagan Thomas, Doherty Edward J, Rein David, Holland Laura: Microporous macrocapsules.. Univ Brown Res Found, October 4, 1995: EP0674497-A1

Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have ...


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Dionne Keith E, Emerich Dwaine F, Hoffman Diane, Sanberg Paul R, Christenson Lisa, Hegre Orion D, Scharp David W, Lacy Paul E, Aebischer Patrick, Vasconcellos Alfred V, Lysaght Michael J, Gentile Frank T: Vehicule implantable, biocompatible et immuno-isolateur pour ladministration de produits therapeutiques selectionnes, Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Brown University Research Foundation, SMART & BIGGAR, November 12, 1992: CA2109085

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide aneeded metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to main-tain the cells, and a permselective, biocompatible, p ...


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Gentile Frank T, Tresco Patrick A, Hazlett Tyrone, Flanagan Thomas, Doherty Edward J, Rein David H, Holland Laura M: Macrocapsules microporeuses, Microporous macrocapsules. Brown University Research Foundation, Brown University Research Foundation, SMART & BIGGAR, May 26, 1994: CA2149420

Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have ...


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Baetge E Edward, Hammang Joseph P, Gentile Frank T, Lindner Mark D, Winn Shelley R, Emerich Dwaine F: Compositions et methodes ameliorees de liberation de molecules biologiquement actives au moyen de cellules genetiquement modifiees contenues dans des capsules dimmunoisolation biocompatibles, Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules. Neurotech Usa, Smart & Biggar, CA2169292

This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule usinga biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect orenhance a biological function within a ...


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