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George Y Lesher, Edward R Bacon, Baldev Singh, Gee Hong Kuo: Imidazopyridines, their preparation and use. Sterling Drug, Philip E Hansen, Paul E Dupont, October 16, 1990: US04963561 (40 worldwide citation)

Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## ...


3
Gee Hong Kuo, Rui Zhang, Aihua Wang, Alan R DeAngelis: 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs. Janssen Pharmaceutical, November 27, 2007: US07301050 (15 worldwide citation)

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.


4
Han Cheng Zhang, Gee Hong Kuo, Bruce E Maryanoff, Hong Ye, David O Neill, Lan Shen, Keith Demarest, Bruce R Conway, David F McComsey: Substituted pyrroline kinase inhibitors. Janssen Pharmaceutica, Yurity Stercho, October 24, 2006: US07125878 (15 worldwide citation)

The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.


5
David J Aldous, Thomas R Bailey, Guy D Diana, Gee Hong Kuo, Theodore J Nitz, Michael Reuman: Antipicornaviral agents. Sterling Winthrop, Richard A Hake, Paul E Dupont, June 4, 1996: US05523312 (11 worldwide citation)

Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1## wherein Het.sub.1 is chosen from the group consisting of oxazolyl, isoxazolyl, oxadiazolyl;


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Gee Hong Kuo, Rui Zhang, Aihua Wang, Alan R DeAngelis: 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs. Janssen Pharmaceutica, December 22, 2009: US07635718 (10 worldwide citation)

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.


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Gee Hong Kuo, Peter J Connolly, Catherine Prouty, Alan DeAngelis, Aihua Wang, Linda Jolliffe, Steve Middleton, Stuart Emanuel: Pyrazine derivatives as modulators of tyrosine kinases. Ortho McNeil Pharmaceutical, March 23, 2004: US06710048 (10 worldwide citation)

The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyraz ...


8
David J Aldous, Thomas R Bailey, Guy D Diana, Gee Hong Kuo, Theodore J Nitz, Michael Reuman: Substituted quinoline derivatives useful as antipiconaviral agents. Sterling Winthrop, Paul E Dupont, William J Davis, May 7, 1996: US05514692 (10 worldwide citation)

The invention discloses compounds of the formula ##STR1## wherein, Het.sub.1 is chosen from the group consisting of substituted or unsubstituted furyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl


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David J Aldous, Thomas R Bailey, Guy D Diana, Theodore J Nitz, Gee Hong Kuo: Therapeutic phenoxyalkylazoles and phenoxyalkylazines. Sterling Winthrop, Richard A Hake, Paul E Dupont, September 3, 1996: US05552420 (10 worldwide citation)

Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl, oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl;


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Gee Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton: 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs. Janssen Pharmaceutica, September 16, 2008: US07425649 (9 worldwide citation)

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.