1
Gautam Mitra: Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer. Miles Laboratories, Lester E Johnson, January 29, 1985: US04496689 (450 worldwide citation)

There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a ...


2
Charles R Wilke, Gautam Mitra: Conversion of cellulosic materials to sugar. The United States of America represented by the United States Energy Research and Development Administration, Dean E Carlson, F A Robertson, Irene S Croft, August 3, 1976: US03972775 (50 worldwide citation)

A process for the production of sugar, mainly glucose, by the enzymatic degradation of cellulosic materials, particularly cellulosic wastes, which comprises hydrolyzing the cellulosic material in the presence of cellulase enzyme to produce a sugar solution and recovering from the hydrolysis products ...


3
Gautam Mitra, Paul K Ng: Pasteurized therapeutically active blood coagulation factor concentrates. Miles Laboratories, Lester E Johnson, Theodore J Leitereg, September 11, 1984: US04470968 (36 worldwide citation)

Compositions containing a concentrate of coagulation Factors II, VII, IX, and X are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol and a source of citrate ions prior to pasteurization. Pasteurized co ...


4
Gautam Mitra: Blood coagulation promoting product. Cutter Laboratories, Theodore J Leitereg, David J Aston, September 13, 1983: US04404132 (25 worldwide citation)

This disclosure pertains to a concentrate for controlling bleeding in hemophilia, free of thrombin, heparin, thromboplastin activity, anticomplement activity, depressor activity, and activated Factor X, and containing coagulation Factors II, VII, IX, and X in non-activated form and containing no gre ...


5
George B Dove, Gautam Mitra: Method of separating proteins from aqueous solutions. Miles Laboratories, Pamela A Simonton, Lester E Johnson, August 4, 1987: US04684723 (23 worldwide citation)

There is disclosed an improved method for separating and recovering proteins, particularly therapeutically active proteins, from an aqueous system also containing a component having the ability to create two liquid phases by use of salt partitioning technology. By the addition of water soluble inorg ...


6
Gautam Mitra, Paul K Ng: Process for producing a high purity antihemophilic factor concentrate. Miles Laboratories, Lester E Johnson, September 24, 1985: US04543210 (22 worldwide citation)

There is disclosed an improved process for producing high purity antihemophilic factor concentrate from an antihemophilic factor-containing dispersion or solution isolated from blood plasma or a blood plasma fraction, wherein the improvement is in carrying-out two consecutive precipitations using a ...


7
James W Bloom, Melvin F Wong, Gautam Mitra: Removal of protein A from antibody preparations. Miles, James A Giblin, Bertram Bradley, January 8, 1991: US04983722 (22 worldwide citation)

Protein A is selectively isolated from an antibody--Protein A mixture by exposing the mixture to an anion exchange material under conditions sufficient to adsorb both components and then sequentially eluting the antibodies and protein A under conditions of increasing ionic strength. Resulting antibo ...


8
Gautam Mitra, John L Lundblad: Antihemophilic factor concentrate and method for preparation. Cutter Laboratories, Theodore J Leitereg, May 31, 1983: US04386068 (18 worldwide citation)

Novel antihemophilic factor concentrates and process for making the same are disclosed. An aqueous solution of antihemophilic factor proteins is obtained, preferably by solubilizing antihemophilic factor proteins from blood plasma cryoprecipitate in water. The aqueous solution is purified to remove ...


9
James W Bloom, Melvin F Wong, Gautam Mitra: Removal of protein A from antibody preparations. Miles, James A Giblin, May 19, 1992: US05115101 (18 worldwide citation)

Antibody preparation purified using immobilized protein A and yet substantially free of protein A that may have solubilized during the purificaiton process. The antibodies include less than 15 ng protein A per mg of antibody, preferably less than 1 ng/mg. Low protein A content is obtained by first c ...


10
Gautam Mitra, Milton M Mozen: Preparation of retrovirus-free immunoglobulins. Miles Laboratories, James A Giblin, August 9, 1988: US04762714 (11 worldwide citation)

Immune serum globulins (ISG) can be made substantially free of infectious retroviruses by preparing the ISG from human plasma using a cold ethanol plasma fractionation process at a pH equal to or less than 5.4 and then storing the ISG at either of two specified storage conditions: (1) at a pH equal ...