1
Santosh K Chandrasekaran, Siegfried Darda, Alan S Michaels, Gary W Cleary: Therapeutic system for administering clonidine transdermally. ALZA Corporation, Boehringer Ingelheim, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, May 6, 1980: US04201211 (201 worldwide citation)

Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm.sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, ...


2
Gary W Cleary, Samir Roy: Transdermal drug-delivery composition. Cygnus Research Corporation, Irell & Manella, March 6, 1990: US04906463 (118 worldwide citation)

A solid state, resilient laminated composite for administering a drug transdermally consisting of a multiplicity of spaced structural laminas of a resilient elastomer, one of which forms the top of the composite, a viscoelastic hydrophobic polymer lamina containing propylene glycol monolaurate inter ...


3
Gary W Cleary, Samir Roy: Resilient transdermal drug delivery device. Cygnus Corporation, Irell & Manella, April 9, 1991: US05006342 (116 worldwide citation)

A solid state, resilient laminated composite for administering a drug transdermally consisting of a multiplicity of spaced structural laminas of a resilient elastomer, one of which forms the top of the composite, a viscoelastic hydrophobic polymer lamina containing propylene glycol monolaurate inter ...


4
Gary W Cleary, Mikhail M Feldstein, Valery G Kulichikhin, Danir F Bairamov: Two-phase, water-absorbent bioadhesive composition. Corium International, A V Topchiev Institute of Petrochemical Synthsis Russian Academy of Sciences, Dianne E Reed, Shelley P Eberle, Reed & Eberle, October 12, 2004: US06803420 (106 worldwide citation)

An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer ca ...


5
Chia Ming Chiang, Gary W Cleary: Skin permeation enhancer compositions. Cygnus Research Corporation, Dianne E Reed, November 27, 1990: US04973468 (98 worldwide citation)

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, m ...


6
Jesus Miranda, Gary W Cleary: Printed transdermal drug delivery device. Cygnus Research Corporation, Dianne E Reed, April 10, 1990: US04915950 (94 worldwide citation)

A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the o ...


7
Chia Ming Chiang, Gary W Cleary: Skin permeation enhancer compositions, and methods and transdermal systems associated therewith. Cygnus Therapeutic Systems, Dianne E Reed, October 1, 1991: US05053227 (77 worldwide citation)

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, m ...


8
Mikhail M Feldstein, Nicolai A Plate, Anatoly E Chalykh, Gary W Cleary: Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties. A V Topchiev Institute of Petrochemical Synthesis, Corium International, Dianne E Reed, Karen Canaan, Reed & Eberle, June 10, 2003: US06576712 (72 worldwide citation)

A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain pla ...


9
Gary W Cleary, Kenneth J Colley, Jesus Miranda: Transdermal delivery device having delayed onset. Cygnus Therapeutic Systems, Morrison & Foerster, December 21, 1993: US05271940 (52 worldwide citation)

A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptured to place the active compound, vehicle, and ...


10
Gary W Cleary, Steven R Klemm: Transdermal delivery device. Corium International, Flavio M Rose, Mintz Levin Cohn Ferris Glovsky and Popeo PC, November 3, 2009: US07611481 (51 worldwide citation)

A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon rem ...